N-(2,4-difluoro-3-(5-(methyl(piperidin-4-yl)amino)-3-(pyrimidin-5-yl)-1H- pyrrolo[3,2-b]pyridin-1-yl)phenyl)propane-1-sulfonamide

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Chemical Name:N-(2,4-difluoro-3-(5-(methyl(piperidin-4-yl)amino)-3-(pyrimidin-5-yl)-1H- pyrrolo[3,2-b]pyridin-1-yl)phenyl)propane-1-sulfonamide
CAS No.:1392429-51-4
Molecular Formula:C₂₆H₂₉F₂N₇O₂S
Molecular Weight:541.625
Hs Code.:

Synonyms:N-(2,4-difluoro-3-(5-(methyl(piperidin-4-yl)amino)-3-(pyrimidin-5-yl)-1H- pyrrolo[3,2-b]pyridin-1-yl)phenyl)propane-1-sulfonamide

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Chemical Property of N-(2,4-difluoro-3-(5-(methyl(piperidin-4-yl)amino)-3-(pyrimidin-5-yl)-1H- pyrrolo[3,2-b]pyridin-1-yl)phenyl)propane-1-sulfonamide

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Technology Process of N-(2,4-difluoro-3-(5-(methyl(piperidin-4-yl)amino)-3-(pyrimidin-5-yl)-1H- pyrrolo[3,2-b]pyridin-1-yl)phenyl)propane-1-sulfonamide

There total 12 articles about N-(2,4-difluoro-3-(5-(methyl(piperidin-4-yl)amino)-3-(pyrimidin-5-yl)-1H- pyrrolo[3,2-b]pyridin-1-yl)phenyl)propane-1-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392429-50-3
4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-3-(pyrimidin-5-yl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

: 1392429-51-4
N-(2,4-difluoro-3-(5-(methyl(piperidin-4-yl)amino)-3-(pyrimidin-5-yl)-1H- pyrrolo[3,2-b]pyridin-1-yl)phenyl)propane-1-sulfonamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1392429-97-8
4-((1-(2,6-difluoro-3-(propylsulfonamido)phenyl)-1H-pyrrolo[3,2-b]pyridin-5-yl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester

: 1392429-51-4
N-(2,4-difluoro-3-(5-(methyl(piperidin-4-yl)amino)-3-(pyrimidin-5-yl)-1H- pyrrolo[3,2-b]pyridin-1-yl)phenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-iodo-succinimide / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 20 °C

2: sodium carbonate; lithium chloride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

3: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 3 h / 20 °C

With hydrogenchloride; N-iodo-succinimide; sodium carbonate; lithium chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; 2: Suzuki Coupling;

Reference yield:

: 1383745-37-6
N-(2,6-difluoro-3-(propylsulfonamido)phenyl)acetamide

: 1392429-51-4
N-(2,4-difluoro-3-(5-(methyl(piperidin-4-yl)amino)-3-(pyrimidin-5-yl)-1H- pyrrolo[3,2-b]pyridin-1-yl)phenyl)propane-1-sulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogenchloride / ethanol; water / 2 h / 80 °C

1.2: pH 6

2.1: sodium nitrite / trifluoroacetic acid / 0.5 h / 0 °C

2.2: 0.25 h

3.1: caesium carbonate; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane / copper(l) iodide / toluene / 40 h / 120 °C / Inert atmosphere

4.1: N-iodo-succinimide / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 20 °C

5.1: sodium carbonate; lithium chloride / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 100 °C / Inert atmosphere

6.1: hydrogenchloride / dichloromethane; 1,4-dioxane; methanol / 3 h / 20 °C

With hydrogenchloride; N-iodo-succinimide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; sodium carbonate; caesium carbonate; lithium chloride; sodium nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; trifluoroacetic acid; 3.1: Ullmann Reaction / 5.1: Suzuki Coupling;