2-(3-chlorophenyl)-5,5-difluoro-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine

Base Information

Chemical Name:2-(3-chlorophenyl)-5,5-difluoro-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine
CAS No.:1303588-46-6
Molecular Formula:C₁₅H₁₃ClF₂N₂
Molecular Weight:294.731
Hs Code.:

Synonyms:2-(3-chlorophenyl)-5,5-difluoro-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine

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Chemical Property of 2-(3-chlorophenyl)-5,5-difluoro-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine

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Technology Process of 2-(3-chlorophenyl)-5,5-difluoro-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine

There total 6 articles about 2-(3-chlorophenyl)-5,5-difluoro-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1303588-45-5
tert-butyl 2-(3-chlorophenyl)-5,5-difluoro-7,8-dihydro-5H-pyrido[2,3-b]azepine-9(6H)-carboxylate

: 1303588-46-6
2-(3-chlorophenyl)-5,5-difluoro-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine

Guidance literature:: With hydrogenchloride; In methanol; at 20 ℃;

Reference yield:

: 45644-21-1
6-chloropyridin-2-amine

: 1303588-46-6
2-(3-chlorophenyl)-5,5-difluoro-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0 °C

1.2: 1 h / 0 - 20 °C

2.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / hexane; tetrahydrofuran / 1.5 h / Cooling with ice

2.2: 19 h / -20 - 20 °C / Reflux

2.3: 20 °C

3.1: sodium dihydrogenphosphate; sodium permanganate / water; tert-butyl alcohol / 50 °C

4.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 18 h / Reflux

5.1: diethylamino-sulfur trifluoride / 144 h / 20 - 44 °C

6.1: hydrogenchloride / methanol / 20 °C

With hydrogenchloride; sodium dihydrogenphosphate; n-butyllithium; sodium permanganate; N,N,N,N,-tetramethylethylenediamine; diethylamino-sulfur trifluoride; sodium hexamethyldisilazane; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; tert-butyl alcohol;

Reference yield:

: 159603-71-1
t-butyl N-(6-chloro-2-pyridinyl)carbamate

: 1303588-46-6
2-(3-chlorophenyl)-5,5-difluoro-6,7,8,9-tetrahydro-5H-pyrido[2,3-b]azepine

Guidance literature:: Multi-step reaction with 5 steps

1.1: N,N,N,N,-tetramethylethylenediamine; n-butyllithium / hexane; tetrahydrofuran / 1.5 h / Cooling with ice

1.2: 19 h / -20 - 20 °C / Reflux

1.3: 20 °C

2.1: sodium dihydrogenphosphate; sodium permanganate / water; tert-butyl alcohol / 50 °C

3.1: caesium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 18 h / Reflux

4.1: diethylamino-sulfur trifluoride / 144 h / 20 - 44 °C

5.1: hydrogenchloride / methanol / 20 °C

With hydrogenchloride; sodium dihydrogenphosphate; n-butyllithium; sodium permanganate; N,N,N,N,-tetramethylethylenediamine; diethylamino-sulfur trifluoride; caesium carbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; methanol; hexane; water; tert-butyl alcohol;