dimethyl 4-(4-fluoro-benzyloxy)-pyridine-2,6-dicarboxylate

Base Information

• Chemical Name: dimethyl 4-(4-fluoro-benzyloxy)-pyridine-2,6-dicarboxylate
• CAS No.: 1236926-61-6
• Molecular Formula: C₁₆H₁₄FNO₅
• Molecular Weight: 319.289
• Mol file: 1236926-61-6.mol

Synonyms:dimethyl 4-(4-fluoro-benzyloxy)-pyridine-2,6-dicarboxylate

Chemical Property of dimethyl 4-(4-fluoro-benzyloxy)-pyridine-2,6-dicarboxylate

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of dimethyl 4-(4-fluoro-benzyloxy)-pyridine-2,6-dicarboxylate

There total 2 articles about dimethyl 4-(4-fluoro-benzyloxy)-pyridine-2,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

4-fluorobenzylic alcohol (459-56-3) + 4-oxo-1,4-dihydro-pyridine-2,6-dicarboxylic acid dimethyl ester (20443-03-2) → dimethyl 4-(4-fluoro-benzyloxy)-pyridine-2,6-dicarboxylate (1236926-61-6)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1039/c002418j

Reference yield:

4-fluorobenzylic alcohol (459-56-3) + Dimethyl 5-hydroxyisophthalate (13036-02-7) → dimethyl 4-(4-fluoro-benzyloxy)-pyridine-2,6-dicarboxylate (1236926-61-6)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 72h; Inert atmosphere;

DOI:10.1039/c2ob25830g

Reference yield: 100.0%

dimethyl 4-(4-fluoro-benzyloxy)-pyridine-2,6-dicarboxylate (1236926-61-6) → 4-(4-fluorobenzyloxy)pyridine-2,6-dicarboxylic acid (1236926-62-7)

Guidance literature:

With water; sodium hydroxide; at 20 ℃;

DOI:10.1039/c002418j

upstream raw materials:

4-fluorobenzylic alcohol

4-oxo-1,4-dihydro-pyridine-2,6-dicarboxylic acid dimethyl ester

Dimethyl 5-hydroxyisophthalate

Downstream raw materials:

4-(4-fluorobenzyloxy)pyridine-2,6-dicarboxylic acid