3-Hydroxy-4-((R)-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-benzoic acid ethyl ester

Base Information

Chemical Name:3-Hydroxy-4-((R)-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-benzoic acid ethyl ester
CAS No.:288299-07-0
Molecular Formula:C₁₇H₂₄O₄
Molecular Weight:292.375
Hs Code.:

Synonyms:3-Hydroxy-4-((R)-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-benzoic acid ethyl ester

Suppliers and Price of 3-Hydroxy-4-((R)-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-benzoic acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Hydroxy-4-((R)-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-benzoic acid ethyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-Hydroxy-4-((R)-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-benzoic acid ethyl ester

There total 8 articles about 3-Hydroxy-4-((R)-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-benzoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 288299-06-9
2-[(E)-3-((R)-2,6,6-Trimethyl-tetrahydro-pyran-2-yl)-prop-2-en-(E)-ylidene]-succinic acid 1-ethyl ester

: 288299-07-0
3-Hydroxy-4-((R)-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-benzoic acid ethyl ester

Guidance literature:: 2-[(E)-3-((R)-2,6,6-Trimethyl-tetrahydro-pyran-2-yl)-prop-2-en-(E)-ylidene]-succinic acid 1-ethyl ester; With triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; at 20 ℃; for 2h;

With sodium tetrahydroborate; In ethanol; for 0.5h;

Reference yield:

: 13837-60-0
2-ethynyl-2,6,6-trimethyl-3,4,5,6-tetrahydro-(2H)-pyran

: 288299-07-0
3-Hydroxy-4-((R)-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 9 steps

1.1: KMnO₄; H₂O / acetone / 4 h / 0 - 20 °C

1.2: (R)-(+)-1-phenylethylamine

2.1: diethyl ether

3.1: LiAlH₄ / diethyl ether

4.1: (COCl)2; DMSO; Et₃N / 2 h / -78 - 20 °C

5.1: CHCl₃ / 8 h / Heating

6.1: DIBALH / 1 h / 0 °C

7.1: MnO₂ / CHCl₃ / 10 h / Heating

8.1: 86 percent / CHCl₃ / 10 h / Heating

9.1: (CF₃CO)2O; Et₃N / tetrahydrofuran / 2 h / 20 °C

9.2: 73 percent / NaBH₄ / ethanol / 0.5 h

With manganese(IV) oxide; potassium permanganate; lithium aluminium tetrahydride; oxalyl dichloride; water; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; diethyl ether; chloroform; acetone; 1.1: Oxidation / 1.2: resolution of racemate / 2.1: Esterification / 3.1: Reduction / 4.1: Swern oxidation / 5.1: Wittig olefination / 6.1: Reduction / 7.1: Oxidation / 8.1: Wittig olefination / 9.1: Aromatisation / 9.2: Reduction;

Reference yield:

: 13226-32-9
(R)-(-)-Cinenic acid methyl ester

: 288299-07-0
3-Hydroxy-4-((R)-2,6,6-trimethyl-tetrahydro-pyran-2-yl)-benzoic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: LiAlH₄ / diethyl ether

2.1: (COCl)2; DMSO; Et₃N / 2 h / -78 - 20 °C

3.1: CHCl₃ / 8 h / Heating

4.1: DIBALH / 1 h / 0 °C

5.1: MnO₂ / CHCl₃ / 10 h / Heating

6.1: 86 percent / CHCl₃ / 10 h / Heating

7.1: (CF₃CO)2O; Et₃N / tetrahydrofuran / 2 h / 20 °C

7.2: 73 percent / NaBH₄ / ethanol / 0.5 h

With manganese(IV) oxide; lithium aluminium tetrahydride; oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; trifluoroacetic anhydride; In tetrahydrofuran; diethyl ether; chloroform; 1.1: Reduction / 2.1: Swern oxidation / 3.1: Wittig olefination / 4.1: Reduction / 5.1: Oxidation / 6.1: Wittig olefination / 7.1: Aromatisation / 7.2: Reduction;