ETHYL 2,4-DIFLUOROIMIDAZOLE 5-CARBOXYLATE

Base Information

Chemical Name:ETHYL 2,4-DIFLUOROIMIDAZOLE 5-CARBOXYLATE
CAS No.:89676-59-5
Molecular Formula:C₆H₆F₂N₂O₂
Molecular Weight:176.123
Hs Code.:2933290090
Mol file:89676-59-5.mol

Synonyms:ETHYL 2,4-DIFLUOROIMIDAZOLE 5-CARBOXYLATE

Suppliers and Price of ETHYL 2,4-DIFLUOROIMIDAZOLE 5-CARBOXYLATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
ETHYL-2,4-DIFLUOROIMIDAZOLE 5-CARBOXYLATE 95.00%
5MG
$ 505.29

Total 8 raw suppliers

Chemical Property of ETHYL 2,4-DIFLUOROIMIDAZOLE 5-CARBOXYLATE

Chemical Property:

Melting Point:107-109 °C
Boiling Point:321.2±52.0 °C(Predicted)
PKA:5.88±0.10(Predicted)
PSA：54.98000
Density:1.422±0.06 g/cm3(Predicted)
LogP:0.86460

Purity/Quality:

97% ^*data from raw suppliers

ETHYL-2,4-DIFLUOROIMIDAZOLE 5-CARBOXYLATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of ETHYL 2,4-DIFLUOROIMIDAZOLE 5-CARBOXYLATE

There total 4 articles about ETHYL 2,4-DIFLUOROIMIDAZOLE 5-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 89676-58-4
ethyl 2-amino-4-fluoroimidazole-5-carboxylate

: 89676-59-5
ethyl 2,4-difluoroimidazole-5-carboxylate

Guidance literature:: With tetrafluoroboric acid; sodium nitrite; at -60 - -40 ℃; for 3h; Irradiation;
DOI:10.1021/jo00185a023

Reference yield:

: 89676-57-3
ethyl 2-<(p-bromophenyl)azo>-4-fluoroimidazole-5-carboxylate

: 89676-59-5
ethyl 2,4-difluoroimidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 65.5 percent / formamidinesulfinic acid (FASA) / NEt₃ / methanol; H₂O / 20 h / 45 - 50 °C

2: 53 percent / 50percent HBF₄ / aq.NaNO₂ / 3 h / -60 - -40 °C / Irradiation

With tetrafluoroboric acid; triethylamine; formamidine; sodium nitrite; In methanol; water;
DOI:10.1021/jo00185a023

Reference yield:

: 21190-16-9
ethyl 4-amino-5-imidazolecarboxylate

: 89676-59-5
ethyl 2,4-difluoroimidazole-5-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 39.2 percent / 50percent HBF₄ / NaNO₂ / H₂O / 4 h / -60 - -40 °C / Irradiation

2: 1) aq.NaNO₂ / 1) 2N HCl (ice-cold) 2) 10percent Na₂CO₃ (ice-cold)

3: 65.5 percent / formamidinesulfinic acid (FASA) / NEt₃ / methanol; H₂O / 20 h / 45 - 50 °C

4: 53 percent / 50percent HBF₄ / aq.NaNO₂ / 3 h / -60 - -40 °C / Irradiation

With tetrafluoroboric acid; triethylamine; formamidine; sodium nitrite; In methanol; water;
DOI:10.1021/jo00185a023