C₂₂H₂₃N₅O₃

Base Information

• Chemical Name: C₂₂H₂₃N₅O₃
• CAS No.: 1316228-41-7
• Molecular Formula: C₂₂H₂₃N₅O₃
• Molecular Weight: 405.456
• Mol file: 1316228-41-7.mol

Synonyms:C₂₂H₂₃N₅O₃

Chemical Property of C₂₂H₂₃N₅O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₂H₂₃N₅O₃

There total 4 articles about C₂₂H₂₃N₅O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-Azaindole (271-63-6) → C22H23N5O3 (1316228-41-7)

Guidance literature:

Multi-step reaction with 5 steps

1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 20 °C

2: dmap / dichloromethane / 1 h / 20 °C

3: copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; triethylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

5: cesium azide / tetrahydrofuran; methanol / 72 h / 20 °C / Inert atmosphere

With dmap; copper(l) iodide; cesium azide; bis(triphenylphosphine)palladium(II) dichloride; tetrabutyl ammonium fluoride; iodine; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 3: Sonogashira coupling;

DOI:10.1039/c1ob05586k

Reference yield:

C17H22N2O2Si → C22H23N5O3 (1316228-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

2: cesium azide / tetrahydrofuran; methanol / 72 h / 20 °C / Inert atmosphere

With cesium azide; tetrabutyl ammonium fluoride; In tetrahydrofuran; methanol;

DOI:10.1039/c1ob05586k

Reference yield:

tert-butyl 3-iodo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate (192189-18-7) → C22H23N5O3 (1316228-41-7)

Guidance literature:

Multi-step reaction with 3 steps

1: copper(l) iodide; bis(triphenylphosphine)palladium(II) dichloride; triethylamine / tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C / Inert atmosphere

3: cesium azide / tetrahydrofuran; methanol / 72 h / 20 °C / Inert atmosphere

With copper(l) iodide; cesium azide; bis(triphenylphosphine)palladium(II) dichloride; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; methanol; 1: Sonogashira coupling;

DOI:10.1039/c1ob05586k

upstream raw materials:

7-Azaindole

tert-butyl 3-iodo-1H-pyrrolo[2,3-b]pyridine-1-carboxylate

3-iodo-1H-pyrrolo[2,3-b]pyridine

Downstream raw materials:

3-(1-(4-methoxybenzyl)-1H-1,2,3-triazol-4-yl)-1H-pyrrolo[2,3-b]pyridine