9-chloro-7-(2-chlorophenyl)-7H-pyrimido<5,4-d><2>benzazepine 3-oxide

Base Information

• Chemical Name: 9-chloro-7-(2-chlorophenyl)-7H-pyrimido<5,4-d><2>benzazepine 3-oxide
• CAS No.: 86709-94-6
• Molecular Formula: C₁₈H₁₁Cl₂N₃O
• Molecular Weight: 356.211
• Mol file: 86709-94-6.mol

Synonyms:9-chloro-7-(2-chlorophenyl)-7H-pyrimido<5,4-d><2>benzazepine 3-oxide

Chemical Property of 9-chloro-7-(2-chlorophenyl)-7H-pyrimido<5,4-d><2>benzazepine 3-oxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-chloro-7-(2-chlorophenyl)-7H-pyrimido<5,4-d><2>benzazepine 3-oxide

There total 5 articles about 9-chloro-7-(2-chlorophenyl)-7H-pyrimido<5,4-d><2>benzazepine 3-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine (76988-39-1) → 9-chloro-7-(2-chlorophenyl)-7H-pyrimido<5,4-d><2>benzazepine 3-oxide (86709-94-6)

Guidance literature:

Multi-step reaction with 5 steps

1: 75 percent / Zn, CH₃COOH / CH₂Cl₂ / 2 h / -30 °C

2: 50 percent / pyridine / CH₂Cl₂ / 1.5 h / 0 °C

3: 21 percent / 85percent m-chloroperbenzoic acid (m-CPBA) / CH₂Cl₂ / 46 h / Ambient temperature

4: 91 percent / 3 N aq. NaOH / ethanol; tetrahydrofuran / 0.5 h / Ambient temperature

5: 1.) Br₂, aq. potassium acetate, 2.) Et₃N / 1.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, 15 min

With pyridine; sodium hydroxide; bromine; potassium acetate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; zinc; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm00365a009

Reference yield:

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine (76988-75-5) → 9-chloro-7-(2-chlorophenyl)-7H-pyrimido<5,4-d><2>benzazepine 3-oxide (86709-94-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 21 percent / 85percent m-chloroperbenzoic acid (m-CPBA) / CH₂Cl₂ / 46 h / Ambient temperature

2: 91 percent / 3 N aq. NaOH / ethanol; tetrahydrofuran / 0.5 h / Ambient temperature

3: 1.) Br₂, aq. potassium acetate, 2.) Et₃N / 1.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, 15 min

With sodium hydroxide; bromine; potassium acetate; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1021/jm00365a009

Reference yield:

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine 3-oxide (76988-78-8) → 9-chloro-7-(2-chlorophenyl)-7H-pyrimido<5,4-d><2>benzazepine 3-oxide (86709-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / 3 N aq. NaOH / ethanol; tetrahydrofuran / 0.5 h / Ambient temperature

2: 1.) Br₂, aq. potassium acetate, 2.) Et₃N / 1.) CH₂Cl₂, RT, 3 h, 2.) CH₂Cl₂, 15 min

With sodium hydroxide; bromine; potassium acetate; triethylamine; In tetrahydrofuran; ethanol;

DOI:10.1021/jm00365a009

upstream raw materials:

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-5H-pyrimido<5,4-d><2>benzazepine 3-oxide

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine

9-chloro-7-(2-chlorophenyl)-6,7-dihydro-6-(trifluoroacetyl)-5H-pyrimido<5,4-d><2>benzazepine 3-oxide

Downstream raw materials:

9-chloro-7-(2-chlorophenyl)-5H-pyrimido<5,4-d><2>benzazepine 3-oxide

5-Amino-8-chloro-1-(2-chloro-phenyl)-1H-benzo[c]azepine-4-carbaldehyde oxime