(S)-4-[5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorobenzenecarbothioic acid hydrazide

Base Information

Chemical Name:(S)-4-[5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorobenzenecarbothioic acid hydrazide
CAS No.:220010-61-7
Molecular Formula:C₁₃H₁₅FN₄O₃S
Molecular Weight:326.352
Hs Code.:

Synonyms:(S)-4-[5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorobenzenecarbothioic acid hydrazide

Suppliers and Price of (S)-4-[5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorobenzenecarbothioic acid hydrazide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-4-[5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorobenzenecarbothioic acid hydrazide

Chemical Property:

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Technology Process of (S)-4-[5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorobenzenecarbothioic acid hydrazide

There total 4 articles about (S)-4-[5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorobenzenecarbothioic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 220010-60-6
4-[(S)-5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-dithiobenzoic acid methyl ester

: 220010-61-7
(S)-4-[5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorobenzenecarbothioic acid hydrazide

Guidance literature:: With hydrazine hydrate; In tetrahydrofuran; dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmcl.2003.07.018

Reference yield:

: 220010-58-2
N-[[(5S)-3-[3-fluoro-4-nitrile-phenyl]-2-oxo-5-oxazolidinyl]methyl] acetamide

: 220010-61-7
(S)-4-[5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorobenzenecarbothioic acid hydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / H₂S; triethylamine / dimethylformamide / 100 °C

2: tetrahydrofuran; CH₂Cl₂ / 0.5 h / 20 °C

3: H₂S; pyridine / tetrahydrofuran; CH₂Cl₂

4: 2.51 g / hydrazine monohydrate / tetrahydrofuran; CH₂Cl₂ / 1 h / 20 °C

With pyridine; hydrogen sulfide; hydrazine hydrate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2003.07.018

Reference yield:

: 220010-59-3
N-[3-(3-fluoro-4-thiocarbamoyl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide

: 220010-61-7
(S)-4-[5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorobenzenecarbothioic acid hydrazide

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; CH₂Cl₂ / 0.5 h / 20 °C

2: H₂S; pyridine / tetrahydrofuran; CH₂Cl₂

3: 2.51 g / hydrazine monohydrate / tetrahydrofuran; CH₂Cl₂ / 1 h / 20 °C

With pyridine; hydrogen sulfide; hydrazine hydrate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.bmcl.2003.07.018