220010-58-2

Upstream product

• 151-50-8 potassium cyanide 
• 181997-31-9 N-{[(5S)-3-(4-amino-3-fluorophenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl}acetamide 

Downstream Products

• 220010-59-3 N-[3-(3-fluoro-4-thiocarbamoyl-phenyl)-2-oxo-oxazolidin-5-ylmethyl]-acetamide 
• 220009-87-0 (S)-N-[[3-[3-Fluoro-4-(1,3,4-thiadiazol-2-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 
• 220010-61-7 (S)-4-[5-[(acetylamino)methyl]-2-oxo-3-oxazolidinyl]-2-fluorobenzenecarbothioic acid hydrazide 
• 220009-99-4 (S)-N-[[3-[3-Fluoro-4-[5-[(methylthio)methyl]-1,3,4-thiadiazol-2-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 
• 220009-91-6 (S)-N-[[3-[4-[5-(Cyanomethyl)-1,3,4-thiadiazol-2-yl]-3-fluorophenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 
• 220009-88-1 (S)-N-[[3-[4-(5-Acetoxymethyl-1,3,4-thiadiazol-2-yl)-3-fluorophenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 
• 220010-05-9 5-{4-[(S)-5-(Acetylamino-methyl)-2-oxo-oxazolidin-3-yl]-2-fluoro-phenyl}-[1,3,4]thiadiazole-2-carboxylic acid ethyl ester 
• 220010-47-9 (S)-N-[[3-[3-Fluoro-4-[5-[(methylsulfonyl)methyl]-1,3,4-thiadiazol-2-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 
• 220009-94-9 (S)-N-[[3-[3-Fluoro-4-[5-(3-oxobutyl)-1,3,4-thiadiazol-2-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]acetamide 

Relevant academic research and scientific papers

The synthesis and antibacterial activity of 1,3,4-thiadiazole phenyl oxazolidinone analogues

Replacement of the morpholine C-ring of linezolid 1 with a 1,3,4-thiadiazolyl ring leads to oxazolidinone analogues 5 having potent antibacterial activity against both gram-positive and gram-negative organisms. Conversion of the C5 acetamide group to a thioacetamide further increases the potency of these compounds.