4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-ethoxybenzamide

Base Information

Chemical Name:4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-ethoxybenzamide
CAS No.:126645-69-0
Molecular Formula:C₂₂H₂₈ClN₃O₃
Molecular Weight:417.936
Hs Code.:

Synonyms:4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-ethoxybenzamide

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Chemical Property of 4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-ethoxybenzamide

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Technology Process of 4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-ethoxybenzamide

There total 7 articles about 4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-ethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 40987-25-5,186293-54-9
N-benzyl-2-chloromethylmorpholine

: 126645-69-0
4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-ethoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 93 percent / potassium iodide / dimethylsulfoxide / 5 h / 120 °C

2: 81 percent / 28percent ammonia water, H₂ / Raney nickel / ethanol / Ambient temperature

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With ammonium hydroxide; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; nickel; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00167a020

Reference yield:

: 104-63-2
N-Benzylethanolamine

: 126645-69-0
4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-ethoxybenzamide

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) concd. H₂SO₄ / 1.) RT, 3 h, 2.) 150 deg C, 1 h

2: 93 percent / potassium iodide / dimethylsulfoxide / 5 h / 120 °C

3: 81 percent / 28percent ammonia water, H₂ / Raney nickel / ethanol / Ambient temperature

4: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With ammonium hydroxide; sulfuric acid; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium iodide; nickel; In ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm00167a020

Reference yield:

: 112887-43-1
2-(2-hydroxyethyl)-4-benzylmorpholine

: 126645-69-0
4-amino-N-[2-(4-benzyl-2-morpholinyl)ethyl]-5-chloro-2-ethoxybenzamide

Guidance literature:: Multi-step reaction with 3 steps

1: 67 percent / diethyl azodicarboxylate, triphenylphosphine / tetrahydrofuran / 20 h / Ambient temperature

2: 13.2 g / 85percent hydrazine monohydrate / ethanol / 1.5 h / Heating

3: 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride / CH₂Cl₂ / 4 h / Ambient temperature

With hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00167a020