3-p-tolylsulfanylcinnoline

Base Information

• Chemical Name: 3-p-tolylsulfanylcinnoline
• CAS No.: 766548-23-6
• Molecular Formula: C₁₅H₁₂N₂S
• Molecular Weight: 252.34
• Mol file: 766548-23-6.mol

Synonyms:3-p-tolylsulfanylcinnoline

Chemical Property of 3-p-tolylsulfanylcinnoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-p-tolylsulfanylcinnoline

There total 2 articles about 3-p-tolylsulfanylcinnoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-chlorocinnoline (17404-90-9) + para-thiocresol (106-45-6) → 3-p-tolylsulfanylcinnoline (766548-23-6)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at 0 - 66 ℃; for 2.16667h;

DOI:10.1016/j.tet.2004.05.059

Reference yield:

3-hydroxycinnoline (31777-46-5) → 3-p-tolylsulfanylcinnoline (766548-23-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / POCl₃ / 240 h / Heating

2: 87 percent / nBuLi / tetrahydrofuran / 2.17 h / 0 - 66 °C

With n-butyllithium; trichlorophosphate; In tetrahydrofuran;

DOI:10.1016/j.tet.2004.05.059

Reference yield: 76.0%

3-p-tolylsulfanylcinnoline (766548-23-6) → 3-p-tolylsulfinylcinnoline (766548-26-9)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -10 ℃; for 0.5h;

DOI:10.1016/j.tet.2004.05.059

upstream raw materials:

3-chlorocinnoline

para-thiocresol

3-hydroxycinnoline

Downstream raw materials:

3-p-tolylsulfinylcinnoline

Refernces