({5-fluoro-2-[(4-methoxyphenyl)sulfinyl]phenyl}ethynyl)(trimethyl)silane

Base Information

Chemical Name:({5-fluoro-2-[(4-methoxyphenyl)sulfinyl]phenyl}ethynyl)(trimethyl)silane
CAS No.:1158986-99-2
Molecular Formula:C₁₈H₁₉FO₂SSi
Molecular Weight:346.498
Hs Code.:

Synonyms:({5-fluoro-2-[(4-methoxyphenyl)sulfinyl]phenyl}ethynyl)(trimethyl)silane

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Chemical Property of ({5-fluoro-2-[(4-methoxyphenyl)sulfinyl]phenyl}ethynyl)(trimethyl)silane

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Technology Process of ({5-fluoro-2-[(4-methoxyphenyl)sulfinyl]phenyl}ethynyl)(trimethyl)silane

There total 4 articles about ({5-fluoro-2-[(4-methoxyphenyl)sulfinyl]phenyl}ethynyl)(trimethyl)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1158986-97-0
1-fluoro-4-((4-methoxyphenyl)sulfinyl)benzene

: 1066-54-2
trimethylsilylacetylene

: 1158986-99-2
({5-fluoro-2-[(4-methoxyphenyl)sulfinyl]phenyl}ethynyl)(trimethyl)silane

Guidance literature:: 1-fluoro-4-((4-methoxyphenyl)sulfinyl)benzene; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at -30 ℃; for 0.333333h; Inert atmosphere;

With TurboGrignard; iodine; In tetrahydrofuran; at -30 - 25 ℃; Inert atmosphere;

trimethylsilylacetylene; Further stages;
DOI:10.1055/s-0028-1087984

Reference yield:

: C₁₃H₁₀FIO₂S

: 1066-54-2
trimethylsilylacetylene

: 1158986-99-2
({5-fluoro-2-[(4-methoxyphenyl)sulfinyl]phenyl}ethynyl)(trimethyl)silane

Guidance literature:: trimethylsilylacetylene; With isopropylmagnesium bromide; In tetrahydrofuran; at 60 ℃; for 0.0833333h; Inert atmosphere;

With zinc(II) chloride; In tetrahydrofuran; at 25 ℃; Inert atmosphere;

C₁₃H₁₀FIO₂S; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; at 50 ℃; for 4h; Inert atmosphere;
DOI:10.1002/chem.201003657

Reference yield:

: 1158986-97-0
1-fluoro-4-((4-methoxyphenyl)sulfinyl)benzene

: 1158986-99-2
({5-fluoro-2-[(4-methoxyphenyl)sulfinyl]phenyl}ethynyl)(trimethyl)silane

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / -30 °C / Inert atmosphere

1.2: 25 °C / Inert atmosphere

2.1: isopropylmagnesium bromide / tetrahydrofuran / 0.08 h / 60 °C / Inert atmosphere

2.2: 25 °C / Inert atmosphere

2.3: 4 h / 50 °C / Inert atmosphere

With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; isopropylmagnesium bromide; In tetrahydrofuran;
DOI:10.1002/chem.201003657