(4-benzenesulfonylphenyl)carbamic acid phenyl ester

Base Information

• Chemical Name: (4-benzenesulfonylphenyl)carbamic acid phenyl ester
• CAS No.: 1439358-24-3
• Molecular Formula: C₁₉H₁₅NO₄S
• Molecular Weight: 353.398
• Mol file: 1439358-24-3.mol

Synonyms:(4-benzenesulfonylphenyl)carbamic acid phenyl ester

Chemical Property of (4-benzenesulfonylphenyl)carbamic acid phenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-benzenesulfonylphenyl)carbamic acid phenyl ester

There total 4 articles about (4-benzenesulfonylphenyl)carbamic acid phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

p-aminophenyl phenyl sulfone (7019-01-4) + phenyl chloroformate (1885-14-9) → (4-benzenesulfonylphenyl)carbamic acid phenyl ester (1439358-24-3)

Guidance literature:

With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.bmcl.2013.04.040

Reference yield:

4-nitrophenyl phenyl sulfone (1146-39-0) → (4-benzenesulfonylphenyl)carbamic acid phenyl ester (1439358-24-3)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / methanol; tetrahydrofuran / 18 h / 20 °C

2: potassium carbonate / tetrahydrofuran / 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; methanol;

DOI:10.1016/j.bmcl.2013.04.040

Reference yield:

sodium benzenesulfonate (873-55-2) → (4-benzenesulfonylphenyl)carbamic acid phenyl ester (1439358-24-3)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethyl sulfoxide / 48 h / 130 °C

2: hydrogen; palladium 10% on activated carbon / methanol; tetrahydrofuran / 18 h / 20 °C

3: potassium carbonate / tetrahydrofuran / 1 h / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In tetrahydrofuran; methanol; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2013.04.040

upstream raw materials:

sodium benzenesulfonate

4-Fluoronitrobenzene

p-aminophenyl phenyl sulfone

phenyl chloroformate

Downstream raw materials:

1-[4-(benzenesulfonyl)phenyl]-3-(pyridin-3-ylmethyl)urea

C₂₀H₁₉N₃O₃S

C₂₀H₁₉N₃O₃S

C₂₀H₁₉N₃O₃S