(S)-2-[2-(2,4-Bis-benzyloxy-phenyl)-acetylamino]-N¹-(5-oxo-pentyl)-succinamide

Base Information

Chemical Name:(S)-2-[2-(2,4-Bis-benzyloxy-phenyl)-acetylamino]-N¹-(5-oxo-pentyl)-succinamide
CAS No.:172992-23-3
Molecular Formula:C₃₁H₃₅N₃O₆
Molecular Weight:545.635
Hs Code.:

(S)-2-[2-(2,4-Bis-benzyloxy-phenyl)-acetylamino]-N<sup>1</sup>-(5-oxo-pentyl)-succinamide

Synonyms:(S)-2-[2-(2,4-Bis-benzyloxy-phenyl)-acetylamino]-N¹-(5-oxo-pentyl)-succinamide

Suppliers and Price of (S)-2-[2-(2,4-Bis-benzyloxy-phenyl)-acetylamino]-N¹-(5-oxo-pentyl)-succinamide

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Chemical Property of (S)-2-[2-(2,4-Bis-benzyloxy-phenyl)-acetylamino]-N¹-(5-oxo-pentyl)-succinamide

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Technology Process of (S)-2-[2-(2,4-Bis-benzyloxy-phenyl)-acetylamino]-N¹-(5-oxo-pentyl)-succinamide

There total 11 articles about (S)-2-[2-(2,4-Bis-benzyloxy-phenyl)-acetylamino]-N¹-(5-oxo-pentyl)-succinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2508-29-4
5-hydroxypentylamine

: 172992-23-3
(S)-2-[2-(2,4-Bis-benzyloxy-phenyl)-acetylamino]-N¹-(5-oxo-pentyl)-succinamide

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / CH₂Cl₂ / 16 h / 20 °C

2: 100 percent / hydrogen / 10 percent Pd/C / methanol / 16 h / 15 °C / 760 Torr

3: 96 percent / Et₃N / dimethylformamide / 16 h / 20 °C

4: 1.) DMSO, oxalyl chloride / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂/DMSO, -78 deg C

With oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(95)01994-S

Reference yield:

: 174007-66-0
[(S)-2-Carbamoyl-1-(5-hydroxy-pentylcarbamoyl)-ethyl]-carbamic acid benzyl ester

: 172992-23-3
(S)-2-[2-(2,4-Bis-benzyloxy-phenyl)-acetylamino]-N¹-(5-oxo-pentyl)-succinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / hydrogen / 10 percent Pd/C / methanol / 16 h / 15 °C / 760 Torr

2: 96 percent / Et₃N / dimethylformamide / 16 h / 20 °C

3: 1.) DMSO, oxalyl chloride / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂/DMSO, -78 deg C

With oxalyl dichloride; hydrogen; dimethyl sulfoxide; triethylamine; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/0040-4039(95)01994-S

Reference yield:

: 89-86-1
4-hydroxysalicylic acid

: 172992-23-3
(S)-2-[2-(2,4-Bis-benzyloxy-phenyl)-acetylamino]-N¹-(5-oxo-pentyl)-succinamide

Guidance literature:: Multi-step reaction with 7 steps

1: 77 percent / NaH / dimethylformamide / 16 h / 0 - 20 °C

2: 1.) aq. NaOH, 2.) aq. HCl / 1.) dioxan, reflux, 90 min

3: oxalyl chloride, pyridine / toluene / 0.5 h / 0 - 20 °C

4: diethyl ether / 2 h / 0 - 20 °C

5: 1.) PhCOOAg / 1.) DMF, 20 deg C, 75 min

6: 96 percent / Et₃N / dimethylformamide / 16 h / 20 °C

7: 1.) DMSO, oxalyl chloride / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂/DMSO, -78 deg C

With pyridine; hydrogenchloride; sodium hydroxide; oxalyl dichloride; silver benzoate; sodium hydride; dimethyl sulfoxide; triethylamine; In diethyl ether; N,N-dimethyl-formamide; toluene;
DOI:10.1016/0040-4039(95)01994-S