10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid sodium salt

Base Information

• Chemical Name: 10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid sodium salt
• CAS No.: 1445586-50-4
• Molecular Formula: C₁₈H₁₅N₆O₂*Na
• Molecular Weight: 370.346
• Mol file: 1445586-50-4.mol

Synonyms:10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid sodium salt

Chemical Property of 10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid sodium salt

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid sodium salt

There total 8 articles about 10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid sodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.5%

10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid bis(dicyclohexylamine) salt → 10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid sodium salt (1445586-50-4)

Guidance literature:

10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid bis(dicyclohexylamine) salt; In N,N-dimethyl acetamide; at 50 - 110 ℃; for 1h;

With water; sodium hydroxide; at 0 - 15 ℃;

Reference yield: 50.3%

4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid (146464-92-8) → 10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid sodium salt (1445586-50-4)

Guidance literature:

4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid; In dimethyl sulfoxide; at 110 - 115 ℃;

With water; sodium hydride; In isopropyl alcohol; at 50 - 55 ℃;

Reference yield:

4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid (146464-93-9) → 10-propargyl-10-carboxy-4-deoxy-4-amino-10-deazapteroic acid sodium salt (1445586-50-4)

Guidance literature:

With sodium hydroxide; In water; at 0 - 20 ℃; for 1.5h;

upstream raw materials:

4-(2-carboxy-1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid

methyl-4-(2-((2,4-diaminopteridin-6-yl)methyl)-1-methoxy-1-oxopent-4-yn-2-yl)benzoate

4-(1-(2,4-diaminopteridin-6-yl)pent-4-yn-2-yl)benzoic acid

methyl 4-(2-methoxy-2-oxoethyl)benzoate

Downstream raw materials:

10-propargyl-10-deazaaminopterin dimethyl ester

pralatrexate