ethyl 2-bromo-3-5'-chloro-6'-hydroxy-3'-phenyl-1',2'-benzisoxazol-7'-ylpropionate

Base Information

Chemical Name:ethyl 2-bromo-3-5'-chloro-6'-hydroxy-3'-phenyl-1',2'-benzisoxazol-7'-ylpropionate
CAS No.:146963-16-8
Molecular Formula:C₁₈H₁₅BrClNO₄
Molecular Weight:424.678
Hs Code.:

Synonyms:ethyl 2-bromo-3-5'-chloro-6'-hydroxy-3'-phenyl-1',2'-benzisoxazol-7'-ylpropionate

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Chemical Property of ethyl 2-bromo-3-5'-chloro-6'-hydroxy-3'-phenyl-1',2'-benzisoxazol-7'-ylpropionate

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Technology Process of ethyl 2-bromo-3-5'-chloro-6'-hydroxy-3'-phenyl-1',2'-benzisoxazol-7'-ylpropionate

There total 12 articles about ethyl 2-bromo-3-5'-chloro-6'-hydroxy-3'-phenyl-1',2'-benzisoxazol-7'-ylpropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 146963-15-7
8-bromo-5-chloro-7,7-diethoxy-3-phenylisoxazolo<5,4-f>chroman

: 146963-16-8
ethyl 2-bromo-3-5'-chloro-6'-hydroxy-3'-phenyl-1',2'-benzisoxazol-7'-ylpropionate

Guidance literature:: With hydrogenchloride; In diethyl ether; for 16h; Ambient temperature;
DOI:10.1248/cpb.40.2597

Reference yield:

: 583-78-8
2,5-dichlorophenol

: 146963-16-8
ethyl 2-bromo-3-5'-chloro-6'-hydroxy-3'-phenyl-1',2'-benzisoxazol-7'-ylpropionate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) AlCl₃, 2.) aq. NaOH / 1.) 1,2-dichloroethane, reflux, 33 h, 2.) EtOH, reflux, 30 min

2: NH₂OH*HCl, pyridine / 2.5 h / Heating

3: KOH / dimethylformamide / 12 h / Heating

4: 97 percent / pivalic acid / toluene / 5 h / Heating

5: 33 percent / Br₂, pyridine / CHCl₃ / 1.) RT, 24 h, 2.) reflux, 13 h

6: 98 percent / aq. HCl / diethyl ether / 16 h / Ambient temperature

With pyridine; hydrogenchloride; potassium hydroxide; sodium hydroxide; aluminium trichloride; hydroxylamine hydrochloride; bromine; Trimethylacetic acid; In diethyl ether; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1248/cpb.40.2597

Reference yield:

: 7051-13-0
1-chloro-2,4-dimethoxybenzene

: 146963-16-8
ethyl 2-bromo-3-5'-chloro-6'-hydroxy-3'-phenyl-1',2'-benzisoxazol-7'-ylpropionate

Guidance literature:: Multi-step reaction with 7 steps

1: AlCl₃ / 1,2-dichloro-ethane / 0 deg C to RT, 3 h, then 50 deg C, 1 h

2: pyridine / 2 h / Heating

3: NH₂OH*HCl, pyridine / 3 h / Heating

4: KOH, N-methyl-2-pyrrolidinone / 5 h / 110 °C

5: 97 percent / pivalic acid / toluene / 5 h / Heating

6: 33 percent / Br₂, pyridine / CHCl₃ / 1.) RT, 24 h, 2.) reflux, 13 h

7: 98 percent / aq. HCl / diethyl ether / 16 h / Ambient temperature

With pyridine; 1-methyl-pyrrolidin-2-one; hydrogenchloride; potassium hydroxide; aluminium trichloride; hydroxylamine hydrochloride; bromine; Trimethylacetic acid; In diethyl ether; chloroform; 1,2-dichloro-ethane; toluene;
DOI:10.1248/cpb.40.2597