N-tert-butyl-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)benzamide

Base Information

Chemical Name:N-tert-butyl-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)benzamide
CAS No.:1425194-11-1
Molecular Formula:C₂₀H₃₁N₃O₂Si
Molecular Weight:373.571
Hs Code.:

Synonyms:N-tert-butyl-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)benzamide

Suppliers and Price of N-tert-butyl-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-tert-butyl-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-tert-butyl-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)benzamide

There total 2 articles about N-tert-butyl-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 42498-38-4
N-(tert-butyl)-4-bromobenzamide

: (1-(2-trimethylsilylethoxymethyl)-pyrazol-5-yl)zinc pivalate

: 1425194-11-1
N-tert-butyl-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)benzamide

Guidance literature:: (1-(2-trimethylsilylethoxymethyl)-pyrazol-5-yl)zinc pivalate; With palladium diacetate; XPhos; In tetrahydrofuran; at 25 ℃; for 0.0333333h; Inert atmosphere; Schlenk technique;

N-(tert-butyl)-4-bromobenzamide; In tetrahydrofuran; at 50 ℃; for 12h; Inert atmosphere; Schlenk technique;
DOI:10.1002/anie.201204526

Reference yield:

: 133560-57-3
1-[(2-(trimethylsilyl)ethoxy)methyl]-1H-pyrazole

: 1425194-11-1
N-tert-butyl-4-(1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazol-5-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex / tetrahydrofuran / 1 h / 25 °C / Inert atmosphere; Schlenk technique

1.2: 0.25 h / 25 °C / Inert atmosphere; Schlenk technique

2.1: palladium diacetate; XPhos / tetrahydrofuran / 0.03 h / 25 °C / Inert atmosphere; Schlenk technique

2.2: 12 h / 50 °C / Inert atmosphere; Schlenk technique

With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; palladium diacetate; XPhos; In tetrahydrofuran; 2.1: |Negishi Coupling / 2.2: |Negishi Coupling;
DOI:10.1002/anie.201204526