rac-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methylmorpholin-3-thione

Base Information

Chemical Name:rac-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methylmorpholin-3-thione
CAS No.:1352419-08-9
Molecular Formula:C₁₇H₁₈N₂O₂S
Molecular Weight:314.408
Hs Code.:

Synonyms:rac-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methylmorpholin-3-thione

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Chemical Property of rac-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methylmorpholin-3-thione

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Technology Process of rac-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methylmorpholin-3-thione

There total 6 articles about rac-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methylmorpholin-3-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1352419-07-8
rac-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methylmorpholin-3-one

: 1352419-08-9
rac-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methylmorpholin-3-thione

Guidance literature:: rac-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methylmorpholin-3-one; With tetraphosphorus decasulfide; In tetrahydrofuran; at 20 - 50 ℃; for 1h;

With pyridine; In tetrahydrofuran; at 80 ℃; for 5h;

Reference yield:

: 2142-63-4
1-(3-Bromophenyl)ethanone

: 1352419-08-9
rac-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methylmorpholin-3-thione

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium chloride / ammonia; methanol / 96 h / 20 °C

2.1: hydrogenchloride / 96 h / Reflux

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C

4.2: 1.5 h / -15 - 0 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere

6.1: tetraphosphorus decasulfide / tetrahydrofuran / 1 h / 20 - 50 °C

6.2: 5 h / 80 °C

With hydrogenchloride; lithium aluminium tetrahydride; tetraphosphorus decasulfide; ammonium chloride; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; methanol; ammonia; water;

Reference yield:

: 953741-63-4
rac-2-amino-2-(3-bromo-phenyl)-propionitrile

: 1352419-08-9
rac-5-[3-(5-methoxypyridin-3-yl)phenyl]-5-methylmorpholin-3-thione

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / 96 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / -15 - 0 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C

3.2: 1.5 h / -15 - 0 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 2 h / 80 °C / Inert atmosphere

5.1: tetraphosphorus decasulfide / tetrahydrofuran / 1 h / 20 - 50 °C

5.2: 5 h / 80 °C

With hydrogenchloride; lithium aluminium tetrahydride; tetraphosphorus decasulfide; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; water;