8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3H-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione

Base Information

• Chemical Name: 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3H-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione
• CAS No.: 1038984-31-4
• Molecular Formula: C₂₀H₁₇FN₄O₃
• Molecular Weight: 380.378

Synonyms:8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3H-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione

Chemical Property of 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3H-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione

Chemical Property:

Purity/Quality:

99%, ^*data from raw suppliers

Tulrampator(CX-1632) >98% ^*data from reagent suppliers

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Technology Process of 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3H-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione

There total 11 articles about 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3H-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-amino-N-4-cyclopropyl-N-1-[2-(3-fluorophenyl)ethyl]-5-hydroxyterephthalamide → 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3H-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione (1038984-31-4)

Guidance literature:

formaldehyd; 2-amino-N-4-cyclopropyl-N-1-[2-(3-fluorophenyl)ethyl]-5-hydroxyterephthalamide; With acetic acid; sodium nitrite; at 20 ℃; for 0.0833333h;

With sulfuric acid; at 80 ℃; for 3h; regioselective reaction;

DOI:10.1021/acs.oprd.9b00241

Reference yield: 92.0%

1,3,5-Trioxan (110-88-3) + N-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-6-hydroxy-4-oxo-1,2,3-benzotriazine-7-carboxamide → 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3H-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione (1038984-31-4)

Guidance literature:

With sulfuric acid; acetic acid; In ethyl acetate; at 40 ℃; for 6h; Solvent; Reagent/catalyst; Temperature; Large scale;

DOI:10.1021/acs.oprd.9b00241

Reference yield:

C20H20FN3O3 → 8-cyclopropyl-3-[2-(3-fluorophenyl)ethyl]-7,8-dihydro-3H-[1,3]oxazino[6,5-g][1,2,3]benzotriazine-4,9-dione (1038984-31-4)

Guidance literature:

With isopentyl nitrite; In N,N-dimethyl-formamide; for 2.5h;

upstream raw materials:

2-bromo-1,4-benzenedicarboxylic acid

formaldehyd

1,3,5-Trioxan

2-bromo-5-nitroterephthalic acid

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