isopropyl 5-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}-2-methylphenyl propylphosphonate

Base Information

Chemical Name:isopropyl 5-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}-2-methylphenyl propylphosphonate
CAS No.:1606168-19-7
Molecular Formula:C₂₄H₃₀N₃O₄P
Molecular Weight:455.494
Hs Code.:

Synonyms:isopropyl 5-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}-2-methylphenyl propylphosphonate

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Chemical Property of isopropyl 5-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}-2-methylphenyl propylphosphonate

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Technology Process of isopropyl 5-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}-2-methylphenyl propylphosphonate

There total 4 articles about isopropyl 5-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}-2-methylphenyl propylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 13213-45-1
(propan-2-yloxy)(propyl)phosphinoyl chloride

: 1606168-13-1
5-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}-2-methylphenol

: 1606168-19-7
isopropyl 5-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}-2-methylphenyl propylphosphonate

Guidance literature:: 5-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}-2-methylphenol; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.5h;

(propan-2-yloxy)(propyl)phosphinoyl chloride; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/jm401742r

Reference yield:

: 75634-03-6
4-chloro-6-(2-methoxy-phenyl)-pyrimidine

: 1606168-19-7
isopropyl 5-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}-2-methylphenyl propylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / isopropyl alcohol; water / 1 h / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/jm401742r

Reference yield:

: 2835-95-2
amino-4 hydroxy-2 toluene

: 1606168-19-7
isopropyl 5-{[6-(2-methoxyphenyl)pyrimidin-4-yl]amino}-2-methylphenyl propylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / isopropyl alcohol; water / 1 h / Reflux

2.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 20 °C

2.2: 20 °C

With hydrogenchloride; potassium tert-butylate; In tetrahydrofuran; water; isopropyl alcohol;
DOI:10.1021/jm401742r