2(S)-2-(benzyloxycarbonylamino)-5-iodovaleric acid benzyl ester

Base Information

• Chemical Name: 2(S)-2-(benzyloxycarbonylamino)-5-iodovaleric acid benzyl ester
• CAS No.: 137452-36-9
• Molecular Formula: C₂₀H₂₂INO₄
• Molecular Weight: 467.303
• Mol file: 137452-36-9.mol

Synonyms:2(S)-2-(benzyloxycarbonylamino)-5-iodovaleric acid benzyl ester

Chemical Property of 2(S)-2-(benzyloxycarbonylamino)-5-iodovaleric acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2(S)-2-(benzyloxycarbonylamino)-5-iodovaleric acid benzyl ester

There total 2 articles about 2(S)-2-(benzyloxycarbonylamino)-5-iodovaleric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

benzyl L-<(2-benzyloxycarbonyl)amino>-5-hydroxypentanoate (167319-89-3) → 2(S)-2-(benzyloxycarbonylamino)-5-iodovaleric acid benzyl ester (137452-36-9)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/jo061037q

Reference yield: 90.0%

5-[(methylsulfonyl)oxy]-N-[(phenylmethoxy)carbonyl]-L-norvaline phenylmethyl ester → 2(S)-2-(benzyloxycarbonylamino)-5-iodovaleric acid benzyl ester (137452-36-9)

Guidance literature:

With sodium iodide; In acetone; for 5h; Heating;

DOI:10.1002/ardp.19953280414

Reference yield: 67.0%

2(S)-2-(benzyloxycarbonylamino)-5-iodovaleric acid benzyl ester (137452-36-9) + (4R)-5-trimethylsilyl-4,5-epoxypent-1-en-3-ones (137452-33-6,137493-78-8,137493-79-9,137493-80-2) → (S)-2-Benzyloxycarbonylamino-8-oxo-8-((S)-3-trimethylsilanyl-oxiranyl)-octanoic acid benzyl ester (137452-44-9,137493-85-7,137566-89-3,137566-90-6)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; Heating;

DOI:10.1039/c39910001277

upstream raw materials:

benzyl L-<(2-benzyloxycarbonyl)amino>-5-hydroxypentanoate

Downstream raw materials:

(S)-2-Benzyloxycarbonylamino-8-oxo-8-((S)-3-trimethylsilanyl-oxiranyl)-octanoic acid benzyl ester

(S)-2-Benzyloxycarbonylamino-8-oxo-8-((R)-3-trimethylsilanyl-oxiranyl)-octanoic acid benzyl ester

(S)-2-Benzyloxycarbonylamino-8-(S)-oxiranyl-8-oxo-octanoic acid benzyl ester

(S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylheptanedioic acid 1-benzyl ester 7-tert-butyl ester