(S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylheptanedioic acid 1-benzyl ester 7-tert-butyl ester

Base Information

Chemical Name:(S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylheptanedioic acid 1-benzyl ester 7-tert-butyl ester
CAS No.:912354-24-6
Molecular Formula:C₃₁H₄₁NO₈
Molecular Weight:555.668
Hs Code.:

Synonyms:(S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylheptanedioic acid 1-benzyl ester 7-tert-butyl ester

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Chemical Property of (S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylheptanedioic acid 1-benzyl ester 7-tert-butyl ester

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Technology Process of (S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylheptanedioic acid 1-benzyl ester 7-tert-butyl ester

There total 2 articles about (S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylheptanedioic acid 1-benzyl ester 7-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 541-16-2
t-butyl malonate

: 137452-36-9
2(S)-2-(benzyloxycarbonylamino)-5-iodovaleric acid benzyl ester

: (S)-1-Phenylacetoxy-pyrrolidine-2-carboxylic acid benzyl ester

: 912354-24-6
(S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylheptanedioic acid 1-benzyl ester 7-tert-butyl ester

Guidance literature:: t-butyl malonate; With sodium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

2(S)-2-(benzyloxycarbonylamino)-5-iodovaleric acid benzyl ester; In tetrahydrofuran; at 20 ℃; for 2h;
DOI:10.1021/jo061037q

Reference yield:

: 167319-89-3
benzyl L-<(2-benzyloxycarbonyl)amino>-5-hydroxypentanoate

: 912354-24-6
(S)-2-benzyloxycarbonylamino-6-tert-butoxycarbonylheptanedioic acid 1-benzyl ester 7-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / I₂; PPh₃; imidazole / tetrahydrofuran / 2 h / 20 °C

2.1: NaHMDS / tetrahydrofuran / 0.5 h / -78 °C

2.2: 50 percent / tetrahydrofuran / 2 h / 20 °C

With 1H-imidazole; iodine; sodium hexamethyldisilazane; triphenylphosphine; In tetrahydrofuran;
DOI:10.1021/jo061037q