[4-(2-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]acetic acid lithium salt

Base Information

Chemical Name:[4-(2-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]acetic acid lithium salt
CAS No.:1251957-81-9
Molecular Formula:C₂₅H₃₇N₂O₃Si*Li
Molecular Weight:448.607
Hs Code.:

Synonyms:[4-(2-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]acetic acid lithium salt

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Chemical Property of [4-(2-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]acetic acid lithium salt

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Technology Process of [4-(2-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]acetic acid lithium salt

There total 8 articles about [4-(2-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]acetic acid lithium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1251957-80-8
ethyl [4-(2-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]acetate

: 1251957-81-9
[4-(2-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]acetic acid lithium salt

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; ethanol; water; at 20 ℃; for 72h;
DOI:10.1021/op1001462

Reference yield:

: 808768-89-0
ethyl [4-(2-amino-2-methylpropyl)phenyl]acetate

: 1251957-81-9
[4-(2-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]acetic acid lithium salt

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; potassium iodide / propiononitrile / 43 h / 110 °C

2: lithium hydroxide / tetrahydrofuran; ethanol; water / 72 h / 20 °C

With potassium carbonate; potassium iodide; lithium hydroxide; In tetrahydrofuran; ethanol; water; propiononitrile;
DOI:10.1021/op1001462

Reference yield:

: 1251957-78-4
(2R)-2-hydroxy-2-(pyridin-2-yl)ethyl 4-methylbenzenesulfonate

: 1251957-81-9
[4-(2-{[(2S)-2-{[tert-butyl(dimethyl)silyl]oxy}-2-(pyridin-2-yl)ethyl]amino}-2-methylpropyl)phenyl]acetic acid lithium salt

Guidance literature:: Multi-step reaction with 3 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 72 h / 20 °C

2: potassium carbonate; potassium iodide / propiononitrile / 43 h / 110 °C

3: lithium hydroxide / tetrahydrofuran; ethanol; water / 72 h / 20 °C

With 1H-imidazole; potassium carbonate; potassium iodide; lithium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; propiononitrile;
DOI:10.1021/op1001462