4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-hydroxybenzonitrile

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Chemical Name:4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-hydroxybenzonitrile
CAS No.:1376514-50-9
Molecular Formula:C₁₉H₂₅N₅O₂
Molecular Weight:355.44
Hs Code.:

Synonyms:4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-hydroxybenzonitrile

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Chemical Property of 4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-hydroxybenzonitrile

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Technology Process of 4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-hydroxybenzonitrile

There total 6 articles about 4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-hydroxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376514-16-7
4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-methoxybenzonitrile

: 1376514-50-9
4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-hydroxybenzonitrile

Guidance literature:: With boron tribromide; In dichloromethane; for 16h;

Reference yield:

: 104436-60-4
4-bromomethyl-3-methoxybenzonitrile

: 1376514-50-9
4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-hydroxybenzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

1.2: 16 h / 70 °C

2.1: methanol / 16 h / 65 °C

3.1: trichlorophosphate / 16 h / 100 °C

3.2: 1 h / 50 °C / pH 7

4.1: 1,4-dioxane / 9 h / 180 °C / Microwave irradiation

5.1: boron tribromide / dichloromethane / 16 h

With boron tribromide; sodium hydride; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; mineral oil;

Reference yield:

: 1376514-13-4
ethyl 2-(4-cyano-2-methoxybenzyl)-3-oxobutanoate

: 1376514-50-9
4-[(2-amino-4-{[(3S)-1-hydroxyhexan-3-yl]amino}-6-methylpyrimidin-5-yl)methyl]-3-hydroxybenzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: methanol / 16 h / 65 °C

2.1: trichlorophosphate / 16 h / 100 °C

2.2: 1 h / 50 °C / pH 7

3.1: 1,4-dioxane / 9 h / 180 °C / Microwave irradiation

4.1: boron tribromide / dichloromethane / 16 h

With boron tribromide; trichlorophosphate; In 1,4-dioxane; methanol; dichloromethane;