2-amino-5-(4-cyano-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-tri(propan-2-yl)-benzenesulfonate

Base Information

Chemical Name:2-amino-5-(4-cyano-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-tri(propan-2-yl)-benzenesulfonate
CAS No.:1376514-24-7
Molecular Formula:C₂₉H₃₆N₄O₄S
Molecular Weight:536.695
Hs Code.:

Synonyms:2-amino-5-(4-cyano-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-tri(propan-2-yl)-benzenesulfonate

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Chemical Property of 2-amino-5-(4-cyano-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-tri(propan-2-yl)-benzenesulfonate

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Technology Process of 2-amino-5-(4-cyano-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-tri(propan-2-yl)-benzenesulfonate

There total 3 articles about 2-amino-5-(4-cyano-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-tri(propan-2-yl)-benzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6553-96-4
2,4,6-triisopropylphenylsulfonyl chloride

: 1376514-14-5
4-[(2-amino-4-hydroxy-6-methylpyrimidin-5-yl)methyl]-3-methoxybenzonitrile

: 1376514-24-7
2-amino-5-(4-cyano-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-tri(propan-2-yl)-benzenesulfonate

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; at 30 ℃; for 7h;

Reference yield:

: 104436-60-4
4-bromomethyl-3-methoxybenzonitrile

: 1376514-24-7
2-amino-5-(4-cyano-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-tri(propan-2-yl)-benzenesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

1.2: 16 h / 70 °C

2.1: methanol / 16 h / 65 °C

3.1: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 7 h / 30 °C

With 1,4-diaza-bicyclo[2.2.2]octane; sodium hydride; In tetrahydrofuran; methanol; mineral oil;

Reference yield:

: 1376514-13-4
ethyl 2-(4-cyano-2-methoxybenzyl)-3-oxobutanoate

: 1376514-24-7
2-amino-5-(4-cyano-2-methoxybenzyl)-6-methylpyrimidin-4-yl 2,4,6-tri(propan-2-yl)-benzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: methanol / 16 h / 65 °C

2: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 7 h / 30 °C

With 1,4-diaza-bicyclo[2.2.2]octane; In tetrahydrofuran; methanol;