(R,E)-2-(benzyloxy)-3,3-difluorobutanal oxime

Base Information

Chemical Name:(R,E)-2-(benzyloxy)-3,3-difluorobutanal oxime
CAS No.:140384-83-4
Molecular Formula:C₁₁H₁₃F₂NO₂
Molecular Weight:229.227
Hs Code.:

Synonyms:(R,E)-2-(benzyloxy)-3,3-difluorobutanal oxime

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,E)-2-(benzyloxy)-3,3-difluorobutanal oxime

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Technology Process of (R,E)-2-(benzyloxy)-3,3-difluorobutanal oxime

There total 4 articles about (R,E)-2-(benzyloxy)-3,3-difluorobutanal oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 138833-07-5
(R)-2-(benzyloxy)-3,3-difluorobutanal

: 140384-83-4
(R,E)-2-(benzyloxy)-3,3-difluorobutanal oxime

Guidance literature:: With 4 A molecular sieve; hydroxylamine; acetic acid; In ethanol;
DOI:10.1021/jo00035a035

Reference yield:

: 100-39-0
benzyl bromide

: 140384-83-4
(R,E)-2-(benzyloxy)-3,3-difluorobutanal oxime

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / NaH / dimethylformamide / 0.17 h / 20 °C

2: 2,4,6-trimethylpyridine / acetonitrile / 0.5 h / Ambient temperature

3: HgCl₂ / H₂O / 2 h / 0 °C

4: 77 percent / NH₂OH, AcOH, molecular sieves (4 Angstroem) / ethanol

With 2,4,6-trimethyl-pyridine; 4 A molecular sieve; hydroxylamine; sodium hydride; acetic acid; mercury dichloride; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00035a035

Reference yield:

: 140176-59-6
(2S)-2-(benzyloxy)-3,3-difluoro-1(R)-<(4-methylphenyl)-sulfinyl>butane

: 140384-83-4
(R,E)-2-(benzyloxy)-3,3-difluorobutanal oxime

Guidance literature:: Multi-step reaction with 3 steps

1: 2,4,6-trimethylpyridine / acetonitrile / 0.5 h / Ambient temperature

2: HgCl₂ / H₂O / 2 h / 0 °C

3: 77 percent / NH₂OH, AcOH, molecular sieves (4 Angstroem) / ethanol

With 2,4,6-trimethyl-pyridine; 4 A molecular sieve; hydroxylamine; acetic acid; mercury dichloride; In ethanol; water; acetonitrile;
DOI:10.1021/jo00035a035