(6S)-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-[(Z)-1-dimethylaminomethylidene]-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

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Chemical Name:(6S)-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-[(Z)-1-dimethylaminomethylidene]-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone
CAS No.:366452-21-3
Molecular Formula:C₂₁H₂₉N₃O₃
Molecular Weight:371.48
Hs Code.:

Synonyms:(6S)-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-[(Z)-1-dimethylaminomethylidene]-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

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Chemical Property of (6S)-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-[(Z)-1-dimethylaminomethylidene]-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

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Technology Process of (6S)-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-[(Z)-1-dimethylaminomethylidene]-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

There total 6 articles about (6S)-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-[(Z)-1-dimethylaminomethylidene]-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 5815-08-7
tert-Butoxybis(dimethylamino)methane

: 281194-62-5
(6S)-N-1-(tert-butoxycarbonyl)-5-phenyl-6-isopropyl-1,2,3,6-tetrahydro-2-pyrazinone

: 366452-21-3
(6S)-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-[(Z)-1-dimethylaminomethylidene]-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

Guidance literature:: In 1,2-dimethoxyethane; at 75 ℃; for 16h;
DOI:10.1016/S0040-4020(01)00553-1

Reference yield: 95.0%

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 281194-62-5
(6S)-N-1-(tert-butoxycarbonyl)-5-phenyl-6-isopropyl-1,2,3,6-tetrahydro-2-pyrazinone

: 366452-21-3
(6S)-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-[(Z)-1-dimethylaminomethylidene]-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

Guidance literature:: In 1,2-dimethoxyethane; at 75 ℃; for 16h;
DOI:10.1016/S0040-4020(01)00553-1

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 366452-21-3
(6S)-N-1-(tert-butoxycarbonyl)-6-isopropyl-3-[(Z)-1-dimethylaminomethylidene]-5-phenyl-1,2,3,6-tetrahydro-2-pyrazinone

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 4-dimethylaminopyridine / tetrahydrofuran / 1.5 h / 0 °C

2: 96 percent / 1,2-dimethoxy-ethane / 16 h / 75 °C

With dmap; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1016/S0040-4020(01)00553-1