2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole

Base Information

Chemical Name:2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole
CAS No.:1392516-38-9
Molecular Formula:C₂₂H₂₁F₃N₄
Molecular Weight:398.431
Hs Code.:

Synonyms:2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole

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Chemical Property of 2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole

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Technology Process of 2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole

There total 4 articles about 2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1392516-37-8
5-bromo-2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-1H-benzimidazole

: 1423-27-4
2-(trifluoromethyl)phenylboronic acid

: 1392516-38-9
2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water; at 90 ℃; for 12h; Inert atmosphere;

Reference yield:

: 175277-11-9
3-(tert-butyl)-1-methyl-1H-pyrazole-5-carboxylic acid

: 1392516-38-9
2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride / 20 °C

1.2: 16 h / 20 °C

1.3: 18 h / 100 °C

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 12 h / 90 °C / Inert atmosphere

With oxalyl dichloride; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,2-dimethoxyethane; water;

Reference yield:

: 133261-10-6
5-tert-butyl-2-methyl-2H-pyrazole-3-carboxylic acid ethyl ester

: 1392516-38-9
2-(5-tert-butyl-2-methyl-2H-pyrazol-3-yl)-5-(2-trifluoromethylphenyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / methanol / 72 h / 20 °C

1.2: pH 2

2.1: oxalyl dichloride / 20 °C

2.2: 16 h / 20 °C

2.3: 18 h / 100 °C

3.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,2-dimethoxyethane; water / 12 h / 90 °C / Inert atmosphere

With oxalyl dichloride; water; sodium carbonate; sodium hydroxide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In methanol; 1,2-dimethoxyethane; water;