(3aR,4S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)hexahydro-[1,3]dioxolo[4,5-a]pyrrolizin-6-one

Base Information

Chemical Name:(3aR,4S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)hexahydro-[1,3]dioxolo[4,5-a]pyrrolizin-6-one
CAS No.:1431853-26-7
Molecular Formula:C₁₇H₂₃NO₃Si
Molecular Weight:317.46
Hs Code.:

Synonyms:(3aR,4S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)hexahydro-[1,3]dioxolo[4,5-a]pyrrolizin-6-one

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Chemical Property of (3aR,4S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)hexahydro-[1,3]dioxolo[4,5-a]pyrrolizin-6-one

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Technology Process of (3aR,4S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)hexahydro-[1,3]dioxolo[4,5-a]pyrrolizin-6-one

There total 1 articles about (3aR,4S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)hexahydro-[1,3]dioxolo[4,5-a]pyrrolizin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 109-87-5
Dimethoxymethane

: 1027340-35-7
(5S,6R,7S,7aR)-6,7-dihydroxy-5-((dimethyl(phenyl)silyl)methyl)-hexahydropyrrolizin-3-one

: 1431853-26-7
(3aR,4S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)hexahydro-[1,3]dioxolo[4,5-a]pyrrolizin-6-one

Guidance literature:: With phosphoric anhydride; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;
DOI:10.1021/jo400386f

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 1431853-26-7
(3aR,4S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)hexahydro-[1,3]dioxolo[4,5-a]pyrrolizin-6-one

: 1431853-27-8
(3aR,4S,6R,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)hexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine-6-carbonitrile

: 1431853-28-9
(3aR,4S,6S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)hexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine-6-carbonitrile

Guidance literature:: (3aR,4S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)hexahydro-[1,3]dioxolo[4,5-a]pyrrolizin-6-one; With n-butyllithium; diisobutylaluminium hydride; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 16h; Inert atmosphere;

trimethylsilyl cyanide; In tetrahydrofuran; hexane; at -60 - 0 ℃; for 1h; Overall yield = 89 %; Overall yield = 0.111 g; Optical yield = 80 %de; Inert atmosphere;
DOI:10.1021/jo400386f