Benzenepropanal, 2-broMo-5-Methoxy-

Base Information

• Chemical Name: Benzenepropanal, 2-broMo-5-Methoxy-
• CAS No.: 146175-93-1
• Molecular Formula: C₁₀H₁₁BrO₂
• Molecular Weight: 243.1
• Mol file: 146175-93-1.mol

Synonyms:3-(2'-bromo-5'-methoxyphenyl)propanal

Chemical Property of Benzenepropanal, 2-broMo-5-Methoxy-

Chemical Property:

• Vapor Pressure: 0.000685mmHg at 25°C

Purity/Quality:

95% ^*data from raw suppliers

3-(2'-Bromo-5'-methoxyphenyl)propionaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzenepropanal, 2-broMo-5-Methoxy-

There total 5 articles about Benzenepropanal, 2-broMo-5-Methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-iodo-4-methoxybromobenzene (4897-68-1) + allyl alcohol (107-18-6) → 3-(2'-bromo-5'-methoxyphenyl)propanal (146175-93-1)

Guidance literature:

With tetrabutyl-ammonium chloride; palladium diacetate; sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 40 - 60 ℃; for 28h;

DOI:10.1021/ja005698v

Reference yield: 80.0%

3-(2'-bromo-5'-methoxyphenyl)propan-1-ol (132934-19-1) → 3-(2'-bromo-5'-methoxyphenyl)propanal (146175-93-1)

Guidance literature:

With 4 A molecular sieve; pyridinium chlorochromate; In dichloromethane; for 3h;

DOI:10.1039/P19920003211

Reference yield:

3-methoxy-1-iodobenzene (766-85-8) → 3-(2'-bromo-5'-methoxyphenyl)propanal (146175-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 96 percent / AcOH; Br₂ / 20 °C

2: 99 percent / tertabutylammonium chloride; sodium bicarbonate; palladium acetate / dimethylformamide / 28 h / 40 - 60 °C

With tetrabutyl-ammonium chloride; bromine; palladium diacetate; sodium hydrogencarbonate; acetic acid; In N,N-dimethyl-formamide;

DOI:10.1021/ja005698v

upstream raw materials:

3-(2'-bromo-5'-methoxyphenyl)propan-1-ol

2-iodo-4-methoxybromobenzene

allyl alcohol

3-methoxy-1-iodobenzene

Downstream raw materials:

3-benzyloxy-7-methoxy-1-methylene-2,3,3a,4,5,9b-hexahydro-1H-benzindene

5-(2'-formyl-5'-methoxyphenyl)-2-methylpent-2-ene

1-(1-hydroxy-2-trimethylsilylmethylprop-2-enyl)-4-methoxy-2-(4-methylpent-3-enyl)benzene

2-(4-benzyloxybut-3-enyl)-1-(1-hydroxy-2-trimethylsilylprop-2-enyl)-4-methoxybenzene