N,N-(2S,13S)-2,13-diformyloxy-4,11-dioxa-3,12-dioxotetradecylene-1,14-diyl-bis(R)-tetrahydropapaverine

Base Information

Chemical Name:N,N-(2S,13S)-2,13-diformyloxy-4,11-dioxa-3,12-dioxotetradecylene-1,14-diyl-bis(R)-tetrahydropapaverine
CAS No.:145554-14-9
Molecular Formula:C₅₄H₆₈N₂O₁₆
Molecular Weight:1001.14
Hs Code.:

Synonyms:N,N-(2S,13S)-2,13-diformyloxy-4,11-dioxa-3,12-dioxotetradecylene-1,14-diyl-bis(R)-tetrahydropapaverine

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Chemical Property of N,N-(2S,13S)-2,13-diformyloxy-4,11-dioxa-3,12-dioxotetradecylene-1,14-diyl-bis(R)-tetrahydropapaverine

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Technology Process of N,N-(2S,13S)-2,13-diformyloxy-4,11-dioxa-3,12-dioxotetradecylene-1,14-diyl-bis(R)-tetrahydropapaverine

There total 3 articles about N,N-(2S,13S)-2,13-diformyloxy-4,11-dioxa-3,12-dioxotetradecylene-1,14-diyl-bis(R)-tetrahydropapaverine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 2565-30-2
formyl chloride

: 145487-81-6,145554-11-6,145554-12-7
3-[(R)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-hydroxy-propionic acid 6-{3-[(R)-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-hydroxy-propionyloxy}-hexyl ester

: 145487-99-6,145554-13-8,145554-14-9
3-[(R)-1-(3,4-Dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-formyloxy-propionic acid 6-{3-[(R)-1-(3,4-dimethoxy-benzyl)-6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl]-2-formyloxy-propionyloxy}-hexyl ester

Guidance literature:: In chloroform; at 50 ℃; for 17h;
DOI:10.1016/0223-5234(92)90180-9

Reference yield: 90.0%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 145554-12-7
N,N-(2S,13S)-2,13-dihydroxy-4,11-dioxa-3,12-dioxotetradecylene-1,14-diyl-bis(R)-tetrahydropapaverine

: 145554-14-9
N,N-(2S,13S)-2,13-diformyloxy-4,11-dioxa-3,12-dioxotetradecylene-1,14-diyl-bis(R)-tetrahydropapaverine

Guidance literature:: With dmap; acetic anhydride; triethylamine; In dichloromethane; 1.) -45 deg C, 1 h, 2.) RT, 1.5 h;
DOI:10.1016/0223-5234(92)90180-9

Reference yield:

: 145488-13-7
(2S,13S)-1,2,13,14-diepoxy-4,11-dioxa-3,12-dioxotetradecylene

: 145554-14-9
N,N-(2S,13S)-2,13-diformyloxy-4,11-dioxa-3,12-dioxotetradecylene-1,14-diyl-bis(R)-tetrahydropapaverine

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / propan-2-ol / 18 h / 60 °C

2: 90 percent / acetic anhydride, triethylamine, N,N-dimethylaminopyridine / CH₂Cl₂ / 1.) -45 deg C, 1 h, 2.) RT, 1.5 h

With dmap; acetic anhydride; triethylamine; In dichloromethane; isopropyl alcohol;
DOI:10.1016/0223-5234(92)90180-9