Technology Process of (2R,3S,6S,10R)-(E)-(+)-10-diphenyl-t-butylsiloxy-8<(5'R)-3',5'-dimethyl-6'-phenylsulphonylhex-2'-enyl>-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan
There total 33 articles about (2R,3S,6S,10R)-(E)-(+)-10-diphenyl-t-butylsiloxy-8<(5'R)-3',5'-dimethyl-6'-phenylsulphonylhex-2'-enyl>-2,3-dimethyl-1,7-dioxaspiro<5.5>undecan which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium peroxomonosulfate;
In
ethanol; water;
at 0 ℃;
for 5h;
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 88 percent / imidazole / dimethylformamide / Ambient temperature
2: 80 percent / dimethylformamide / 12 h / 70 °C
3: di-isobutylaluminium hydride / CH2Cl2 / 5 h / Ambient temperature; 1.) -78 deg C --> room temp., 1 h
4: CH2Cl2 / 0 deg C, then room temp. overnight
5: 60 percent / di-isobutylaluminium hydride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / -78 deg C --> room temp., overnight
6: triethylamine, dimethylaminopyridine / CH2Cl2 / 0 °C
7: sodium iodide / tetrahydrofuran / 12 h
8: 80 percent / tetrahydrofuran / -20 °C
9: lithium aluminium hydride / diethyl ether / 1 h / 0 °C
10: pyridine / 0 °C
11: 90 percent / sodium / methanol / Ambient temperature
12: 90 percent / KHSO5 / H2O; ethanol / 5 h / 0 °C
With
1H-imidazole; dmap; lithium aluminium tetrahydride; potassium peroxomonosulfate; diisobutylaluminum hydride; sodium; triethylamine; sodium iodide;
In
tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: CH2Cl2 / 0 deg C, then room temp. overnight
2: 60 percent / di-isobutylaluminium hydride / tetrahydrofuran; diethyl ether / 1 h / -78 °C / -78 deg C --> room temp., overnight
3: triethylamine, dimethylaminopyridine / CH2Cl2 / 0 °C
4: sodium iodide / tetrahydrofuran / 12 h
5: 80 percent / tetrahydrofuran / -20 °C
6: lithium aluminium hydride / diethyl ether / 1 h / 0 °C
7: pyridine / 0 °C
8: 90 percent / sodium / methanol / Ambient temperature
9: 90 percent / KHSO5 / H2O; ethanol / 5 h / 0 °C
With
dmap; lithium aluminium tetrahydride; potassium peroxomonosulfate; diisobutylaluminum hydride; sodium; triethylamine; sodium iodide;
In
tetrahydrofuran; pyridine; methanol; diethyl ether; ethanol; dichloromethane; water;
