N-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide

Base Information

Chemical Name:N-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide
CAS No.:1159599-53-7
Molecular Formula:C₂₃H₂₅N₃O₄
Molecular Weight:407.469
Hs Code.:

Synonyms:N-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide

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Chemical Property of N-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide

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Technology Process of N-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide

There total 5 articles about N-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1159599-33-3
6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide

: 74-88-4
methyl iodide

: 1159599-53-7
N-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide

Guidance literature:: 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide; With potassium hexamethylsilazane; In tetrahydrofuran; at 0 ℃; for 0.533333h;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

: 1159599-10-6
6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid

: 1159599-53-7
N-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / 0 °C

2.2: 2 h / 20 °C

With potassium hexamethylsilazane; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 18718-79-1
5-methyl-3-phenyl-4-isoxazolylmethanol

: 1159599-53-7
N-methyl-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-N-(tetrahydro-pyran-4-yl)-nicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / mineral oil / 5 h / 20 °C

2.1: sodium hydroxide / ethanol; water / 2 h / Reflux

3.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

4.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / 0 °C

4.2: 2 h / 20 °C

With potassium hexamethylsilazane; sodium hydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; mineral oil;