tert-butyl (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate

Base Information

• Chemical Name: tert-butyl (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate
• CAS No.: 252279-24-6
• Molecular Formula: C₂₄H₂₅N₃O₂S
• Molecular Weight: 419.547
• Mol file: 252279-24-6.mol

Synonyms:tert-butyl (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate

Chemical Property of tert-butyl (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate

There total 2 articles about tert-butyl (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-benzo[b]thiophen-3-yl-2-tert-butoxycarbonylamino-propionic acid 2-oxo-2-phenyl-ethyl ester (1025821-02-6) → tert-butyl (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate (252279-24-6)

Guidance literature:

With ammonium acetate; In xylene; for 0.75h; Heating;

DOI:10.1021/jm0108449

Reference yield:

(2R)-3-(Benzo[b]thiophen-3-yl)-2-tert-butoxycarbonylamino-propionic acid → tert-butyl (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate (252279-24-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Cs₂CO₃ / ethanol / 0.5 h / 20 °C

1.2: dimethylformamide / 1 h / 20 °C

2.1: NH₄OAc / xylene / 0.75 h / Heating

With ammonium acetate; caesium carbonate; In ethanol; xylene;

DOI:10.1021/jm0108449

Reference yield: 80.0%

tert-butyl (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate (252279-24-6) → (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine dihydrochloride (252279-34-8)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 ℃;

DOI:10.1021/jm0108449

upstream raw materials:

3-benzo[b]thiophen-3-yl-2-tert-butoxycarbonylamino-propionic acid 2-oxo-2-phenyl-ethyl ester

Downstream raw materials:

(1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine dihydrochloride

(1R)-2-(1-Benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine HCl