(1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine dihydrochloride

Base Information

• Chemical Name: (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine dihydrochloride
• CAS No.: 252279-34-8
• Molecular Formula: C₁₉H₁₇N₃S
• Molecular Weight: 319.43
• Mol file: 252279-34-8.mol

Synonyms:(1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine dihydrochloride

Chemical Property of (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine dihydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine dihydrochloride

There total 2 articles about (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

tert-butyl (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate (252279-24-6) → (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine dihydrochloride (252279-34-8)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 ℃;

DOI:10.1021/jm0108449

Reference yield:

(2R)-3-(Benzo[b]thiophen-3-yl)-2-tert-butoxycarbonylamino-propionic acid → (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)-1-ethanamine dihydrochloride (252279-34-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: Cs₂CO₃ / ethanol / 0.5 h / 20 °C

1.2: dimethylformamide / 1 h / 20 °C

2.1: NH₄OAc / xylene / 0.75 h / Heating

3.1: 80 percent / HCl(g) / ethyl acetate / 0 °C

With hydrogenchloride; ammonium acetate; caesium carbonate; In ethanol; ethyl acetate; xylene;

DOI:10.1021/jm0108449

upstream raw materials:

tert-butyl (1R)-2-(1-benzothiophen-3-yl)-1-(4-phenyl-1H-imidazol-2-yl)ethylcarbamate