3-(3,2''-diisobutyl-4-methoxy-2'-naphthalen-1-ylmethyl-[1,1':4',1'']-terphenyl-4''-yl)propionitrile

Base Information

Chemical Name:3-(3,2''-diisobutyl-4-methoxy-2'-naphthalen-1-ylmethyl-[1,1':4',1'']-terphenyl-4''-yl)propionitrile
CAS No.:475272-43-6
Molecular Formula:C₄₁H₄₃NO
Molecular Weight:565.799
Hs Code.:

Synonyms:3-(3,2''-diisobutyl-4-methoxy-2'-naphthalen-1-ylmethyl-[1,1':4',1'']-terphenyl-4''-yl)propionitrile

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Chemical Property of 3-(3,2''-diisobutyl-4-methoxy-2'-naphthalen-1-ylmethyl-[1,1':4',1'']-terphenyl-4''-yl)propionitrile

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Technology Process of 3-(3,2''-diisobutyl-4-methoxy-2'-naphthalen-1-ylmethyl-[1,1':4',1'']-terphenyl-4''-yl)propionitrile

There total 14 articles about 3-(3,2''-diisobutyl-4-methoxy-2'-naphthalen-1-ylmethyl-[1,1':4',1'']-terphenyl-4''-yl)propionitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.23%

: 475272-04-9
2-(3-isobutyl-4-methoxyphenyl)-4,4,5,5-tetramethyl-[1,3,2]dioxaborolane

: 475272-42-5
trifluoro-methanesulfonic acid 4'-(2-cyano-ethyl)-2'-isobutyl-3-naphthalen-1-ylmethyl-biphenyl-4-yl-ester

: 475272-43-6
3-(3,2''-diisobutyl-4-methoxy-2'-naphthalen-1-ylmethyl-[1,1':4',1'']-terphenyl-4''-yl)propionitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; ethanol; at 80 ℃; for 9h;
DOI:10.1021/ja050122x

Reference yield:

: 475272-40-3
3-(2-isobutyl-4'-methoxy-3'-naphthalen-1-yl-methylbiphenyl-4-yl)propionitrile

: 475272-43-6
3-(3,2''-diisobutyl-4-methoxy-2'-naphthalen-1-ylmethyl-[1,1':4',1'']-terphenyl-4''-yl)propionitrile

Guidance literature:: Multi-step reaction with 3 steps

1: BBr₃ / CH₂Cl₂ / 0 - 20 °C

2: DIEA / CH₂Cl₂

3: Cs₂CO₃ / Pd(PPh₃)4 / dimethylformamide

With boron tribromide; caesium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; 3: Suzuki coupling;
DOI:10.1002/anie.200462316

Reference yield:

: 475272-41-4
3-(4'-hydroxy-2-isobutyl-3'-naphthalen-1-ylmethylbiphenyl-4-yl)-propionitrile

: 475272-43-6
3-(3,2''-diisobutyl-4-methoxy-2'-naphthalen-1-ylmethyl-[1,1':4',1'']-terphenyl-4''-yl)propionitrile

Guidance literature:: Multi-step reaction with 2 steps

1: DIEA / CH₂Cl₂

2: Cs₂CO₃ / Pd(PPh₃)4 / dimethylformamide

With caesium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1002/anie.200462316