trifluoro-methanesulfonic acid 4'-(2-cyano-ethyl)-2'-isobutyl-3-naphthalen-1-ylmethyl-biphenyl-4-yl-ester

Base Information

Chemical Name:trifluoro-methanesulfonic acid 4'-(2-cyano-ethyl)-2'-isobutyl-3-naphthalen-1-ylmethyl-biphenyl-4-yl-ester
CAS No.:475272-42-5
Molecular Formula:C₃₁H₂₈F₃NO₃S
Molecular Weight:551.629
Hs Code.:

Synonyms:trifluoro-methanesulfonic acid 4'-(2-cyano-ethyl)-2'-isobutyl-3-naphthalen-1-ylmethyl-biphenyl-4-yl-ester

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Chemical Property of trifluoro-methanesulfonic acid 4'-(2-cyano-ethyl)-2'-isobutyl-3-naphthalen-1-ylmethyl-biphenyl-4-yl-ester

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Technology Process of trifluoro-methanesulfonic acid 4'-(2-cyano-ethyl)-2'-isobutyl-3-naphthalen-1-ylmethyl-biphenyl-4-yl-ester

There total 13 articles about trifluoro-methanesulfonic acid 4'-(2-cyano-ethyl)-2'-isobutyl-3-naphthalen-1-ylmethyl-biphenyl-4-yl-ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.81%

: 475272-41-4
3-(4'-hydroxy-2-isobutyl-3'-naphthalen-1-ylmethylbiphenyl-4-yl)-propionitrile

: 358-23-6
trifluoromethylsulfonic anhydride

: 475272-42-5
trifluoro-methanesulfonic acid 4'-(2-cyano-ethyl)-2'-isobutyl-3-naphthalen-1-ylmethyl-biphenyl-4-yl-ester

Guidance literature:: In pyridine; at 0 - 20 ℃; for 20h;
DOI:10.1021/ja050122x

Reference yield:

: 434300-54-6
4-(2-cyanoethyl)-2-isobutylphenyl trifluoromethanesulfonate

: 475272-42-5
trifluoro-methanesulfonic acid 4'-(2-cyano-ethyl)-2'-isobutyl-3-naphthalen-1-ylmethyl-biphenyl-4-yl-ester

Guidance literature:: Multi-step reaction with 3 steps

1: Cs₂CO₃ / Pd(PPh₃)4 / dimethylformamide / 110 °C

2: BBr₃ / CH₂Cl₂ / 0 - 20 °C

3: DIEA / CH₂Cl₂

With boron tribromide; caesium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide; 1: Suzuki coupling;
DOI:10.1002/anie.200462316

Reference yield:

: 475272-03-8
4-iodo-2-isobutylanisole

: 475272-42-5
trifluoro-methanesulfonic acid 4'-(2-cyano-ethyl)-2'-isobutyl-3-naphthalen-1-ylmethyl-biphenyl-4-yl-ester

Guidance literature:: Multi-step reaction with 7 steps

1: Bu₄NCl; NaHCO₃ / Pd(OAc)2 / dimethylformamide / 40 °C

2: Mg / methanol / 20 °C

3: BBr₃ / CH₂Cl₂ / 20 °C

4: pyridine / 20 °C

5: Cs₂CO₃ / Pd(PPh₃)4 / dimethylformamide / 110 °C

6: BBr₃ / CH₂Cl₂ / 0 - 20 °C

7: DIEA / CH₂Cl₂

With pyridine; tetrabutyl-ammonium chloride; boron tribromide; sodium hydrogencarbonate; caesium carbonate; magnesium; N-ethyl-N,N-diisopropylamine; palladium diacetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; N,N-dimethyl-formamide; 5: Suzuki coupling;
DOI:10.1002/anie.200462316