6-cyclohexyl-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile

Base Information

Chemical Name:6-cyclohexyl-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile
CAS No.:592509-73-4
Molecular Formula:C₃₂H₃₆NOP
Molecular Weight:481.618
Hs Code.:

6-cyclohexyl-3-oxo-2-(triphenyl-λ<sup>5</sup>-phosphanylidene)-octanenitrile

Synonyms:6-cyclohexyl-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile

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Chemical Property of 6-cyclohexyl-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile

Chemical Property:

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Technology Process of 6-cyclohexyl-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile

There total 7 articles about 6-cyclohexyl-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 6293-41-0
4-cyclohexyl-hexanoic acid

: 16640-68-9
cyanomethylene triphenylphosphorane

: 592509-73-4
6-cyclohexyl-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃;
DOI:10.1021/jo0347011

Reference yield:

: 33856-70-1
2-Cyclohexyl-butanal

: 592509-73-4
6-cyclohexyl-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / toluene / Heating

2: 74 percent / H₂ / Pd/C / methanol / 20 °C

3: 95 percent / LiOH*H₂O; H₂O / tetrahydrofuran; ethanol / 20 °C

4: 87 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 4-dimethylaminopyridine / CH₂Cl₂ / 20 °C

With dmap; lithium hydroxide; water; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; toluene;
DOI:10.1021/jo0347011

Reference yield:

: 14352-61-5
methyl cyclohexylacetate

: 592509-73-4
6-cyclohexyl-3-oxo-2-(triphenyl-λ⁵-phosphanylidene)-octanenitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: LDA; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone / tetrahydrofuran; hexane / 1 h / -78 °C

1.2: 95 percent / tetrahydrofuran; hexane / 14 h / -78 - 20 °C

2.1: 83 percent / diisobutylaluminum hydride / CH₂Cl₂; toluene / 0 - 20 °C

3.1: 81 percent / PDC; celite / CH₂Cl₂ / 1 h / 20 °C

4.1: 88 percent / toluene / Heating

5.1: 74 percent / H₂ / Pd/C / methanol / 20 °C

6.1: 95 percent / LiOH*H₂O; H₂O / tetrahydrofuran; ethanol / 20 °C

7.1: 87 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 4-dimethylaminopyridine / CH₂Cl₂ / 20 °C

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; lithium hydroxide; dipyridinium dichromate; Celite; water; hydrogen; diisobutylaluminium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium diisopropyl amide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; toluene;
DOI:10.1021/jo0347011