N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-[4-(1H-1-tetrazolyl)phenyl]aminoacetamide

Base Information

Chemical Name:N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-[4-(1H-1-tetrazolyl)phenyl]aminoacetamide
CAS No.:377079-03-3
Molecular Formula:C₂₁H₂₁F₂N₉O₂
Molecular Weight:469.454
Hs Code.:

Synonyms:N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-[4-(1H-1-tetrazolyl)phenyl]aminoacetamide

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Chemical Property of N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-[4-(1H-1-tetrazolyl)phenyl]aminoacetamide

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Technology Process of N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-[4-(1H-1-tetrazolyl)phenyl]aminoacetamide

There total 3 articles about N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-[4-(1H-1-tetrazolyl)phenyl]aminoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 127000-91-3
(2R,3R)-3-Amino-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-2-butanol

: 377079-02-2
N-[4-(1H-1-tetrazolyl)phenyl]glycine

: 377079-03-3
N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-[4-(1H-1-tetrazolyl)phenyl]aminoacetamide

Guidance literature:: With triethylamine; diethyl dicarbonate; In N,N-dimethyl-formamide; at 0 ℃; for 1h;
DOI:10.1248/cpb.49.1110

Reference yield:

: 377078-98-3
ethyl N-[4-(1H-1-tetrazolyl)phenyl]glycinate

: 377079-03-3
N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-[4-(1H-1-tetrazolyl)phenyl]aminoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / 1N aq. NaOH / tetrahydrofuran; methanol / 0.5 h / 20 °C

2: 88 percent / DEPC; Et₃N / dimethylformamide / 1 h / 0 °C

With sodium hydroxide; triethylamine; diethyl dicarbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.49.1110

Reference yield:

: 14213-13-9
4-tetrazol-1-yl-phenylamine

: 377079-03-3
N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-[4-(1H-1-tetrazolyl)phenyl]aminoacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / Et₃N / tetrahydrofuran / 16 h / 50 °C

2: 74 percent / 1N aq. NaOH / tetrahydrofuran; methanol / 0.5 h / 20 °C

3: 88 percent / DEPC; Et₃N / dimethylformamide / 1 h / 0 °C

With sodium hydroxide; triethylamine; diethyl dicarbonate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.49.1110