14213-13-9

Basic information

• Product Name: 4-(1H-TETRAZOL-1-YL)ANILINE HYDROCHLORIDE
• Synonyms: 4-(1H-Tetrazol-1-yl)benzenamine;4-(1H-Tetrazole-1-yl)aniline;4-(1H-tetrazol-1-yl)aniline(SALTDATA: FREE);[4-(1H-tetrazol-1-yl)phenyl]amine;[4-(tetrazol-1-yl)phenyl]amine;4-(1,2,3,4-tetrazol-1-yl)aniline;4-(1H-Tetraazol-1-yl)aniline;4-(1-tetrazolyl)aniline
• CAS NO: 14213-13-9
• Molecular Formula: C₇H₇N₅
• Molecular Weight: 161.16
• Mol File: 14213-13-9.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 373.8°C at 760 mmHg
• Flash Point: 179.8°C
• Appearance: /
• Density: 1.46g/cm³
• Vapor Pressure: 8.76E-06mmHg at 25°C
• Refractive Index: 1.749
• Storage Temp.: 2-8°C
• PKA: 2.95±0.10(Predicted)
• CAS DataBase Reference: 4-(1H-TETRAZOL-1-YL)ANILINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(1H-TETRAZOL-1-YL)ANILINE HYDROCHLORIDE(14213-13-9)
• EPA Substance Registry System: 4-(1H-TETRAZOL-1-YL)ANILINE HYDROCHLORIDE(14213-13-9)

Safety Data

• Hazardous Substances Data: 14213-13-9(Hazardous Substances Data)

Usage

General Description

4-(1H-Tetrazol-1-yl)aniline hydrochloride is a chemical compound that belongs to the class of tetrazole derivatives. It is a white crystalline solid that is soluble in water and ethanol. 4-(1H-TETRAZOL-1-YL)ANILINE HYDROCHLORIDE is often used as a building block in organic synthesis and pharmaceutical research. It has been studied for its potential application in the development of new drugs and as an intermediate in the synthesis of various organic compounds. Additionally, 4-(1H-Tetrazol-1-yl)aniline hydrochloride has been investigated for its antimicrobial and antitumor properties, making it a compound of interest in the field of medicinal chemistry.

InChI:InChI=1/C7H7N5/c8-6-1-3-7(4-2-6)12-5-9-10-11-12/h1-5H,8H2

Upstream product

• 14213-11-7 1-(4-nitrophenyl)-1H-tetrazole 
• 288-94-8 1H-tetrazole 
• 350-46-9 4-Fluoronitrobenzene 
• 100-01-6 4-nitro-aniline 
• 309742-07-2 N-[4-(1H-tetrazol-1-yl)phenyl]acetamide 
• 106-50-3 1,4-phenylenediamine 
• 149-73-5 trimethyl orthoformate 
• 5378-52-9 phenyl-1H-tetrazole 
• 14210-25-4 5-Chloro-1-phenyltetrazole 
• 128828-52-4 N,N-dibenzyl-p-phenylenediamine 
• 65052-89-3 N,N-dibenzyl-4-nitroaniline 
• 217654-46-1 1-[4-(N,N-dibenzylamino)phenyl]-1H-tetrazole 
• 14210-30-1 5-chloro-1-(4-nitrophenyl)tetrazole 

Downstream Products

• 288-94-8 1H-tetrazole 
• 21788-29-4 p-phenylenebis-1H-tetrazole 
• 217654-45-0 phenyl 4-(1H-1-tetrazolyl)phenylcarbamate 
• 377079-04-4 tert-butyl N-[4-(1H-1-tetrazolyl)phenyl]glycinate 
• 377078-98-3 ethyl N-[4-(1H-1-tetrazolyl)phenyl]glycinate 
• 377079-02-2 N-[4-(1H-1-tetrazolyl)phenyl]glycine 
• 377079-06-6 N-ethoxycarbonyl-N-[4-(1H-1-tetrazolyl)phenyl]glycine 
• 377079-05-5 tert-butyl N-ethoxycarbonyl-N-[4-(1H-1-tetrazolyl)phenyl]glycinate 
• 377079-03-3 N-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-2-[4-(1H-1-tetrazolyl)phenyl]aminoacetamide 
• 377079-08-8 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-tetrazolyl)phenyl]-2,5-imidazolidinedione 
• 377079-07-7 ethyl N-[2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]amino-2-oxoethyl]-N-[4-(1H-tetrazolyl)phenyl]carbamate 
• 181869-53-4 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-(1H,3H)-imidazolone 
• 181869-54-5 1-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-3-[4-(1H-1-tetrazolyl)phenyl]-2-imidazolidinone 
• 181870-66-6 1-[4-(1H-1-tetrazolyl)phenyl]-2(1H,3H)-imidazolone 

Relevant articles and documents

Design and biological evaluation of tetrahydropyridine derivatives as novel human GPR119 agonists

A series of novel tetrahydropyridine derivatives were prepared and evaluated using cell-based measurements. Systematic optimization of general structure G-1 led to the identification of compound 35 (EC50 = 4.9 nM) and 37 (EC50 = 8.8 nM) with high GPR119 agonism activity and moderate clog P. Through single and long-term pharmacodynamic experiments, we found that compound 35 showed a hypoglycemic effect and may have an effect on improving basal metabolic rate in DIO mice. Both in vitro and in vivo tests indicated that compound 35 was a potential potent GPR119 agonist in allusion to T2DM treatment.

Synthesis and transformations of 1-(azidophenyl)-1H-tetrazoles

Diazotization of 1-(aminophenyl)-1H-tetrazoles and subsequent treatment of the diazonium salts with sodium azide gave 1-(azidophenyl)-1H-tetrazoles which were brought into cyclization with ethyl acetoacetate and cyanoacetanilide to obtain 1,2,3-triazole derivatives. Under these conditions, the tetrazole ring may undergo cleavage with formation of cyanamide group.

Optically active antifungal azoles. X. Synthesis and antifungal activity of N-[4-(azolyl)phenyl]- and N-[4-(azolylmethyl)phenyl]-N′-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy -1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-azolones

New optically active antifungal azoles, N-[4-(azolyl)phenyl]- and N-[4-(azolylmethyl)phenyl]-N′-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy -1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]azolones (1, 2, 3), were prepared in a stereocontrolled manner. Compounds 1