2-benzyl-6-oxo-2,3,5,6,7,8-hexahydro-1H-isoquinoline-8a-carboxylic acid methyl ester 6-ethylene ketal

Base Information

• Chemical Name: 2-benzyl-6-oxo-2,3,5,6,7,8-hexahydro-1H-isoquinoline-8a-carboxylic acid methyl ester 6-ethylene ketal
• CAS No.: 223788-46-3
• Molecular Formula: C₂₀H₂₅NO₄
• Molecular Weight: 343.423

Synonyms:2-benzyl-6-oxo-2,3,5,6,7,8-hexahydro-1H-isoquinoline-8a-carboxylic acid methyl ester 6-ethylene ketal

Chemical Property of 2-benzyl-6-oxo-2,3,5,6,7,8-hexahydro-1H-isoquinoline-8a-carboxylic acid methyl ester 6-ethylene ketal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-benzyl-6-oxo-2,3,5,6,7,8-hexahydro-1H-isoquinoline-8a-carboxylic acid methyl ester 6-ethylene ketal

There total 2 articles about 2-benzyl-6-oxo-2,3,5,6,7,8-hexahydro-1H-isoquinoline-8a-carboxylic acid methyl ester 6-ethylene ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

ethylene glycol (107-21-1) + 2-benzyl-6-oxo-2,3,4,6,7,8-hexahydro-1H-isoquinoline-8a-carboxylic acid methyl ester (223788-42-9) → 2-benzyl-6-oxo-2,3,5,6,7,8-hexahydro-1H-isoquinoline-8a-carboxylic acid methyl ester 6-ethylene ketal (223788-46-3)

Guidance literature:

With chloro-trimethyl-silane; for 15h; Ambient temperature;

DOI:10.1021/jo982055d

Reference yield:

1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester (57611-47-9) → 2-benzyl-6-oxo-2,3,5,6,7,8-hexahydro-1H-isoquinoline-8a-carboxylic acid methyl ester 6-ethylene ketal (223788-46-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / NaH / methanol / 2 h / Heating

2: 85 percent / TMSCl / 15 h / Ambient temperature

With chloro-trimethyl-silane; sodium hydride; In methanol;

DOI:10.1021/jo982055d

Reference yield: 91.0%

2-benzyl-6-oxo-2,3,5,6,7,8-hexahydro-1H-isoquinoline-8a-carboxylic acid methyl ester 6-ethylene ketal (223788-46-3) → 2-benzyl-8a-(hydroxymethyl)-2,3,5,6,7,8-hexahydro-1H-isoquinolin-6-one 6-ethylene ketal (223788-49-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.5h; Ambient temperature;

DOI:10.1021/jo982055d

upstream raw materials:

ethylene glycol

2-benzyl-6-oxo-2,3,4,6,7,8-hexahydro-1H-isoquinoline-8a-carboxylic acid methyl ester

1-benzyl-4-oxo-piperidine-3-carboxylic acid methyl ester

Downstream raw materials:

2-benzyl-8a-(hydroxymethyl)-2,3,5,6,7,8-hexahydro-1H-isoquinolin-6-one 6-ethylene ketal

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 223788-46-3 2-benzyl-6-oxo-2,3,5,6,7,8-hexahydro-1H-isoquinoline-8a-carboxylic acid methyl ester 6-ethylene ketal

Send

Send

Metric Ton KG G Pound L ML

Send

Send