2-{[(Tert-butoxy)carbonyl]amino}-3-hydroxy-2-methylpropanoic acid

Base Information

Chemical Name:2-{[(Tert-butoxy)carbonyl]amino}-3-hydroxy-2-methylpropanoic acid
CAS No.:89500-39-0
Molecular Formula:C9H17 N O5
Molecular Weight:219.23498
Hs Code.:
European Community (EC) Number:850-953-9
Mol file:89500-39-0.mol

Synonyms:89500-39-0;2-{[(tert-butoxy)carbonyl]amino}-3-hydroxy-2-methylpropanoic acid;Serine, N-[(1,1-dimethylethoxy)carbonyl]-2-methyl- (9CI);2-((tert-butoxycarbonyl)amino)-3-hydroxy-2-methylpropanoic acid;3-hydroxy-2-methyl-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid;BOC-ALPHA-METHYL-D-SER;2-([(TERT-BUTOXY)CARBONYL]AMINO)-3-HYDROXY-2-METHYLPROPANOIC ACID;SCHEMBL201901;FWRXDSRYWWYTPD-UHFFFAOYSA-N;AKOS022653228;CS-0137987;EN300-181907;G41164;Z1508688559;2-{[(tert-butoxy)carbonyl]amino}-3-hydroxy-2-methylpropanoicacid

Suppliers and Price of 2-{[(Tert-butoxy)carbonyl]amino}-3-hydroxy-2-methylpropanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
Boc-N-Me-DL-Ser-OH
250mg
$ 353.00

Total 5 raw suppliers

Chemical Property of 2-{[(Tert-butoxy)carbonyl]amino}-3-hydroxy-2-methylpropanoic acid

Chemical Property:

PSA：95.86000
Density:1.207±0.06 g/cm3 (20 ºC 760 Torr)
LogP:0.73760
XLogP3:0.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:219.11067264
Heavy Atom Count:15
Complexity:258

Purity/Quality:

98%Min ^*data from raw suppliers

Boc-N-Me-DL-Ser-OH ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC(C)(CO)C(=O)O

Technology Process of 2-{[(Tert-butoxy)carbonyl]amino}-3-hydroxy-2-methylpropanoic acid

There total 2 articles about 2-{[(Tert-butoxy)carbonyl]amino}-3-hydroxy-2-methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5424-29-3
2-amino-3-hydroxy-2-methyl-propionic acid

: 24424-99-5
di-tert-butyl dicarbonate

: 89500-39-0
2-((tert-butoxycarbonyl)amino)-3-hydroxy-2-methylpropanoic acid

Guidance literature:: 2-amino-3-hydroxy-2-methyl-propionic acid; With sodium carbonate; In water; at 20 ℃;

di-tert-butyl dicarbonate; In 1,4-dioxane; water; at 20 ℃;

With hydrogenchloride; In 1,4-dioxane; water;
DOI:10.1016/j.bmc.2009.04.015

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 89500-39-0
2-((tert-butoxycarbonyl)amino)-3-hydroxy-2-methylpropanoic acid

Guidance literature:: 2-amino-3-hydroxy-2-methyl-propionic acid; With N,O-bis(trimethylsilyl)trifluoroacetamide; In dichloromethane; for 1h; Heating / reflux;

di-tert-butyl dicarbonate; In dichloromethane; at 20 ℃;

Reference yield:

: 89500-39-0
2-((tert-butoxycarbonyl)amino)-3-hydroxy-2-methylpropanoic acid

: 1449475-98-2
3',4'-diamino-3-fluoro-[1,1'-biphenyl]-4-carbonitrile

: 1449475-79-9
tert-butyl (2-(5-(4-cyano-3-fluorophenyl)-1H-benzo[d]imidazol-2-yl)-1-hydroxypropan-2-yl)carbamate

Guidance literature:: 2-((tert-butoxycarbonyl)amino)-3-hydroxy-2-methylpropanoic acid; 3',4'-diamino-3-fluoro-[1,1'-biphenyl]-4-carbonitrile; With 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In ethyl acetate; N,N-dimethyl-formamide; at 20 ℃; for 18h;

With acetic acid; at 65 ℃; for 2h;