12-Benzyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizine-4-thione

Base Information

• Chemical Name: 12-Benzyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizine-4-thione
• CAS No.: 145471-52-9
• Molecular Formula: C₂₂H₂₀N₂S
• Molecular Weight: 344.48
• Mol file: 145471-52-9.mol

Synonyms:12-Benzyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizine-4-thione

Chemical Property of 12-Benzyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizine-4-thione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 12-Benzyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizine-4-thione

There total 2 articles about 12-Benzyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizine-4-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

12-Benzyl-2,3,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizine-4-thione → 12-Benzyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizine-4-thione (145471-52-9)

Guidance literature:

With 4-methylbenzenesulfinyl chloride; N-ethyl-N,N-diisopropylamine; Yield given;

DOI:10.1016/S0040-4039(00)61004-3

Reference yield:

12-benzyl-2,3,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizine-4-one (145471-55-2) → 12-Benzyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizine-4-thione (145471-52-9)

Guidance literature:

Multi-step reaction with 2 steps

1: Lawesson's reagent

2: p-toluenesulfinyl chloride, iPr₂NEt

With Lawessons reagent; 4-methylbenzenesulfinyl chloride; N-ethyl-N,N-diisopropylamine;

DOI:10.1016/S0040-4039(00)61004-3

Reference yield: 100.0%

12-Benzyl-6,7,12,12b-tetrahydro-1H-indolo[2,3-a]quinolizine-4-thione (145471-52-9) + malonic acid dimethyl ester (108-59-8) → 2-((2R,12bS)-12-Benzyl-4-thioxo-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizin-2-yl)-malonic acid dimethyl ester (145471-53-0)

Guidance literature:

With caesium carbonate; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1016/S0040-4039(00)61004-3

upstream raw materials:

12-benzyl-2,3,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizine-4-one

Downstream raw materials:

2-((2R,12bS)-12-Benzyl-4-thioxo-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizin-2-yl)-malonic acid dimethyl ester

2-((2S,12bS)-12-Benzyl-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizin-2-yl)-malonic acid dimethyl ester