3-(2-dibenzylamino-2-methoxycarbonyl-ethyl)-1H-indole-2-carboxylic acid methyl ester

Base Information

Chemical Name:3-(2-dibenzylamino-2-methoxycarbonyl-ethyl)-1H-indole-2-carboxylic acid methyl ester
CAS No.:645394-83-8
Molecular Formula:C₂₈H₂₈N₂O₄
Molecular Weight:456.541
Hs Code.:

3-(2-dibenzylamino-2-methoxycarbonyl-ethyl)-1<i>H</i>-indole-2-carboxylic acid methyl ester

Synonyms:3-(2-dibenzylamino-2-methoxycarbonyl-ethyl)-1H-indole-2-carboxylic acid methyl ester

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Chemical Property of 3-(2-dibenzylamino-2-methoxycarbonyl-ethyl)-1H-indole-2-carboxylic acid methyl ester

Chemical Property:

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Technology Process of 3-(2-dibenzylamino-2-methoxycarbonyl-ethyl)-1H-indole-2-carboxylic acid methyl ester

There total 1 articles about 3-(2-dibenzylamino-2-methoxycarbonyl-ethyl)-1H-indole-2-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 74-88-4
methyl iodide

: 3-(2-dibenzylamino-2-methoxycarbonyl-ethyl)-1H-indole-2-carboxylic acid

: 645394-83-8
3-(2-dibenzylamino-2-methoxycarbonyl-ethyl)-1H-indole-2-carboxylic acid methyl ester

Guidance literature:: With potassium hydrogencarbonate; In N,N-dimethyl-formamide;
DOI:10.1002/anie.200352423

Reference yield:

: 645394-83-8
3-(2-dibenzylamino-2-methoxycarbonyl-ethyl)-1H-indole-2-carboxylic acid methyl ester

: 206535-31-1
microsclerodermin E

Guidance literature:: Multi-step reaction with 13 steps

1.1: 70 percent / H₂ / Pd(OH)2 / methanol

2.1: 96 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotrazole; diisopropylethylamine

3.1: LiOH / methanol; H₂O

4.1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotrazole; diisopropylethylamine

5.1: trifluoroacetic acid

6.1: Bu₄NF; TsOH

6.2: pentafluorophenol; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

6.3: NaHCO₃ / dimethylformamide / 45 °C

7.1: trifluoroacetic acid

8.1: 80 percent / NaHCO₃ / acetonitrile

9.1: Bu₄NF / tetrahydrofuran

10.1: trimethylphosphine / tetrahydrofuran

11.1: diphenylphosphoryl azide / dimethylformamide / 336 h

12.1: LiOH / methanol; tetrahydrofuran

13.1: Amberlyst-15 / methanol; H₂O

With lithium hydroxide; amberlyst-15; diphenylphosphoranyl azide; tetrabutyl ammonium fluoride; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trimethylphosphane; palladium dihydroxide; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/anie.200352423

Reference yield:

: 645394-83-8
3-(2-dibenzylamino-2-methoxycarbonyl-ethyl)-1H-indole-2-carboxylic acid methyl ester

: C₅₁H₆₆N₈O₁₆

Guidance literature:: Multi-step reaction with 10 steps

1.1: 70 percent / H₂ / Pd(OH)2 / methanol

2.1: 96 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotrazole; diisopropylethylamine

3.1: LiOH / methanol; H₂O

4.1: 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; 1-hydroxybenzotrazole; diisopropylethylamine

5.1: trifluoroacetic acid

6.1: Bu₄NF; TsOH

6.2: pentafluorophenol; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

6.3: NaHCO₃ / dimethylformamide / 45 °C

7.1: trifluoroacetic acid

8.1: 80 percent / NaHCO₃ / acetonitrile

9.1: Bu₄NF / tetrahydrofuran

10.1: trimethylphosphine / tetrahydrofuran

With lithium hydroxide; tetrabutyl ammonium fluoride; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; trimethylphosphane; palladium dihydroxide; In tetrahydrofuran; methanol; water; acetonitrile;
DOI:10.1002/anie.200352423