(R)-2-Benzyl-3-amino-1-propanol

Base Information

Chemical Name:(R)-2-Benzyl-3-amino-1-propanol
CAS No.:158045-02-4
Molecular Formula:C₁₀H₁₅NO
Molecular Weight:165.235
Hs Code.:
DSSTox Substance ID:DTXSID501293665
Nikkaji Number:J1.207.503K

Synonyms:158045-02-4;(R)-2-Benzyl-3-amino-1-propanol;(R)-3-amino-2-benzylpropan-1-ol;(2R)-2-(aminomethyl)-3-phenylpropan-1-ol;Benzenepropanol, beta-(aminomethyl)-, (betaR)-;DTXSID501293665;(betaR)-beta-(Aminomethyl)benzenepropanol

Suppliers and Price of (R)-2-Benzyl-3-amino-1-propanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of (R)-2-Benzyl-3-amino-1-propanol

Chemical Property:

XLogP3:0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:165.115364102
Heavy Atom Count:12
Complexity:110

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)CC(CN)CO
Isomeric SMILES:C1=CC=C(C=C1)C[C@H](CN)CO

Technology Process of (R)-2-Benzyl-3-amino-1-propanol

There total 5 articles about (R)-2-Benzyl-3-amino-1-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 173216-45-0,173216-46-1
(R)-3-azido-2-benzylpropanol

: 158045-02-4
(R)-3-amino-2-benzylpropane

Guidance literature:: With water; triphenylphosphine; In tetrahydrofuran; at 50 ℃; for 6h;
DOI:10.1016/S0957-4166(99)00371-7

Reference yield:

: 2612-30-8
2-benzyl-1,3-propanediol

: 158045-02-4
(R)-3-amino-2-benzylpropane

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / 3A molecular sieves; lipase Amono P supported on Celite / various solvent(s) / 5.7 h / 25 °C

2: Et₃N / CH₂Cl₂ / 2.5 h / -30 °C

3: 96 percent / sodium azide / dimethylformamide / 50 °C

4: 99 percent / pH 7 buffer; lipase Amano P / 22 h / 20 °C / pH 7

5: 94 percent / H₂O, PPh₃ / tetrahydrofuran / 6 h / 50 °C

With sodium azide; 3 A molecular sieve; lipase Amano P; lipase Amono P supported on Celite; pH 7 buffer; water; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: Acylation / 2: mesylation / 3: Substitution / 4: Hydrolysis / 5: Staudinger reaction;
DOI:10.1016/S0957-4166(99)00371-7

Reference yield:

: 110270-49-0
(R)-3-acetoxy-2-benzyl-1-propanol

: 158045-02-4
(R)-3-amino-2-benzylpropane

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 2.5 h / -30 °C

2: 96 percent / sodium azide / dimethylformamide / 50 °C

3: 99 percent / pH 7 buffer; lipase Amano P / 22 h / 20 °C / pH 7

4: 94 percent / H₂O, PPh₃ / tetrahydrofuran / 6 h / 50 °C

With sodium azide; lipase Amano P; pH 7 buffer; water; triethylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1: mesylation / 2: Substitution / 3: Hydrolysis / 4: Staudinger reaction;
DOI:10.1016/S0957-4166(99)00371-7