6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazine-3-carbohydrazide

Base Information

Chemical Name:6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazine-3-carbohydrazide
CAS No.:960492-87-9
Molecular Formula:C₁₆H₁₆F₃N₅O
Molecular Weight:351.331
Hs Code.:

Synonyms:6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazine-3-carbohydrazide

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Chemical Property of 6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazine-3-carbohydrazide

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Technology Process of 6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazine-3-carbohydrazide

There total 7 articles about 6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazine-3-carbohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl 6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazine-3-carboxylate

: 960492-87-9
6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazine-3-carbohydrazide

Guidance literature:: With hydrazine; In methanol; at 20 ℃; for 4h;

Reference yield:

: 1121-79-5
3-chloro-6-methylpyridazine

: 960492-87-9
6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazine-3-carbohydrazide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium dichromate; sulfuric acid / 3.33 h / 60 - 65 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

3: dichloromethane / 1 h / 0 - 10 °C

4: potassium carbonate / 1,4-dioxane / 48 h / Heating / reflux

5: hydrazine / methanol / 4 h / 20 °C

With potassium dichromate; oxalyl dichloride; sulfuric acid; potassium carbonate; hydrazine; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; dichloromethane;

Reference yield:

: 5096-73-1
6-chloro-pyridazine-3-carboxylic acid

: 960492-87-9
6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazine-3-carbohydrazide

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

2: dichloromethane / 1 h / 0 - 10 °C

3: potassium carbonate / 1,4-dioxane / 48 h / Heating / reflux

4: hydrazine / methanol / 4 h / 20 °C

With oxalyl dichloride; potassium carbonate; hydrazine; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; dichloromethane;