2-oxo-2-{2-[(6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}ethyl acetate

Base Information

Chemical Name:2-oxo-2-{2-[(6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}ethyl acetate
CAS No.:960492-88-0
Molecular Formula:C₂₀H₂₀F₃N₅O₄
Molecular Weight:451.405
Hs Code.:

Synonyms:2-oxo-2-{2-[(6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}ethyl acetate

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Chemical Property of 2-oxo-2-{2-[(6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}ethyl acetate

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Technology Process of 2-oxo-2-{2-[(6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}ethyl acetate

There total 8 articles about 2-oxo-2-{2-[(6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}ethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 960492-87-9
6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazine-3-carbohydrazide

: 13831-31-7
Acetoxyacetyl chloride

: 960492-88-0
2-oxo-2-{2-[(6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}ethyl acetate

Guidance literature:: In dichloromethane; water; for 0.5h;

Reference yield:

: 1121-79-5
3-chloro-6-methylpyridazine

: 960492-88-0
2-oxo-2-{2-[(6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}ethyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1: potassium dichromate; sulfuric acid / 3.33 h / 60 - 65 °C

2: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 0.5 h / 20 °C

3: dichloromethane / 1 h / 0 - 10 °C

4: potassium carbonate / 1,4-dioxane / 48 h / Heating / reflux

5: hydrazine / methanol / 4 h / 20 °C

6: dichloromethane; water / 0.5 h

With potassium dichromate; oxalyl dichloride; sulfuric acid; potassium carbonate; hydrazine; N,N-dimethyl-formamide; In 1,4-dioxane; methanol; dichloromethane; water;

Reference yield:

: 960492-83-5
tert-butyl 3-[2-(trifluoromethyl)benzylidene]azetidine-1-carboxylate

: 960492-88-0
2-oxo-2-{2-[(6-{3-[2-(trifluoromethyl)benzyl]azetidin-1-yl}pyridazin-3-yl)carbonyl]hydrazino}ethyl acetate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 16 h / 2068.65 Torr

2: hydrogenchloride / 1,4-dioxane; dichloromethane / 18 h

3: potassium carbonate / 1,4-dioxane / 48 h / Heating / reflux

4: hydrazine / methanol / 4 h / 20 °C

5: dichloromethane; water / 0.5 h

With hydrogenchloride; hydrogen; potassium carbonate; hydrazine; palladium 10% on activated carbon; In 1,4-dioxane; methanol; dichloromethane; water; ethyl acetate;