(E)-diethyl (3-(1-(benzyloxy)-3-ethylureido)prop-1-en-1-yl)phosphonate

Base Information

• Chemical Name: (E)-diethyl (3-(1-(benzyloxy)-3-ethylureido)prop-1-en-1-yl)phosphonate
• CAS No.: 1639810-61-9
• Molecular Formula: C₁₇H₂₇N₂O₅P
• Molecular Weight: 370.386
• Mol file: 1639810-61-9.mol

Synonyms:(E)-diethyl (3-(1-(benzyloxy)-3-ethylureido)prop-1-en-1-yl)phosphonate

Chemical Property of (E)-diethyl (3-(1-(benzyloxy)-3-ethylureido)prop-1-en-1-yl)phosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-diethyl (3-(1-(benzyloxy)-3-ethylureido)prop-1-en-1-yl)phosphonate

There total 3 articles about (E)-diethyl (3-(1-(benzyloxy)-3-ethylureido)prop-1-en-1-yl)phosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diethyl (E)-(3-((benzyloxy)amino)prop-1-en-1-yl)phosphonate (1639810-56-2) + ethyl isocyanate (109-90-0) → (E)-diethyl (3-(1-(benzyloxy)-3-ethylureido)prop-1-en-1-yl)phosphonate (1639810-61-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1039/c4ra00757c

Reference yield:

N-benzyloxyamine (622-33-3) → (E)-diethyl (3-(1-(benzyloxy)-3-ethylureido)prop-1-en-1-yl)phosphonate (1639810-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

1.3: 2 h / Inert atmosphere

2.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

In methanol; dichloromethane;

DOI:10.1039/c4ra00757c

Reference yield:

(E)-diethyl (3-oxoprop-1-en-1-yl)phosphonate → (E)-diethyl (3-(1-(benzyloxy)-3-ethylureido)prop-1-en-1-yl)phosphonate (1639810-61-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanol / 1 h / 0 - 20 °C / Inert atmosphere

1.2: 0.5 h / 20 °C / Inert atmosphere

1.3: 2 h / Inert atmosphere

2.1: dichloromethane / 3 h / 20 °C / Inert atmosphere

In methanol; dichloromethane;

DOI:10.1039/c4ra00757c

upstream raw materials:

diethyl (E)-(3-((benzyloxy)amino)prop-1-en-1-yl)phosphonate

ethyl isocyanate

N-benzyloxyamine

Downstream raw materials:

(+/-)-diethyl ((1-(benzyloxy)-3-ethyl-2-oxoimidazolidin-4-yl)-methyl)phosphonate