4-(3-fluoro-2-methoxyphenyl)-4-methyl-2-(trifluoromethyl)-2-trimethylsilyloxy-pentanoic acid ethylester

Base Information

Chemical Name:4-(3-fluoro-2-methoxyphenyl)-4-methyl-2-(trifluoromethyl)-2-trimethylsilyloxy-pentanoic acid ethylester
CAS No.:825654-74-8
Molecular Formula:C₁₉H₂₈F₄O₄Si
Molecular Weight:424.508
Hs Code.:

Synonyms:4-(3-fluoro-2-methoxyphenyl)-4-methyl-2-(trifluoromethyl)-2-trimethylsilyloxy-pentanoic acid ethylester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(3-fluoro-2-methoxyphenyl)-4-methyl-2-(trifluoromethyl)-2-trimethylsilyloxy-pentanoic acid ethylester

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Technology Process of 4-(3-fluoro-2-methoxyphenyl)-4-methyl-2-(trifluoromethyl)-2-trimethylsilyloxy-pentanoic acid ethylester

There total 1 articles about 4-(3-fluoro-2-methoxyphenyl)-4-methyl-2-(trifluoromethyl)-2-trimethylsilyloxy-pentanoic acid ethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.8%

: 825654-73-7
(E/Z)-4-(3-fluoro-2-methoxyphenyl)-4-methyl-2-oxo-pentanoic acid ethylester

: 81290-20-2
(trifluoromethyl)trimethylsilane

: 825654-74-8
4-(3-fluoro-2-methoxyphenyl)-4-methyl-2-(trifluoromethyl)-2-trimethylsilyloxy-pentanoic acid ethylester

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 5 ℃; for 2.5h;

Reference yield: 87.1%

: 825654-74-8
4-(3-fluoro-2-methoxyphenyl)-4-methyl-2-(trifluoromethyl)-2-trimethylsilyloxy-pentanoic acid ethylester

: 825654-75-9
4-(3-fluoro-2-methoxyphenyl)-4-methyl-2-(trifluoromethyl)-2-trimethylsilyloxy-pentan-1-ol

Guidance literature:: 4-(3-fluoro-2-methoxyphenyl)-4-methyl-2-(trifluoromethyl)-2-trimethylsilyloxy-pentanoic acid ethylester; With lithium aluminium tetrahydride; In diethyl ether; at 0 - 20 ℃; for 4.5h;

With potassium carbonate; In diethyl ether; water; at 0 - 20 ℃;