(2’R)-2’-azido-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)thymidine

Base Information

Chemical Name:(2’R)-2’-azido-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)thymidine
CAS No.:1300590-49-1
Molecular Formula:C₄₂H₄₇N₅O₆Si
Molecular Weight:745.951
Hs Code.:

Synonyms:(2’R)-2’-azido-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)thymidine

Suppliers and Price of (2’R)-2’-azido-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)thymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2’R)-2’-azido-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)thymidine

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Technology Process of (2’R)-2’-azido-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)thymidine

There total 10 articles about (2’R)-2’-azido-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1300590-46-8
3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)-5-methyl-2’-O-(trifluoromethanesulfonyl)arabinouridine

: 1300590-49-1
(2’R)-2’-azido-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)thymidine

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 20 ℃; for 13h; Inert atmosphere;

Reference yield:

: 287737-62-6
2-((3aR,5R,6S,6aR)-6-(benzyloxy)-5-((benzyloxy)methyl)-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethanol

: 1300590-49-1
(2’R)-2’-azido-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)thymidine

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap; triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2.1: acetic anhydride; sulfuric acid; acetic acid / 2 h / 20 °C / Inert atmosphere

3.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 1.5 h / Inert atmosphere; Reflux

3.2: 3.5 h / 0 °C / Reflux; Inert atmosphere

4.1: potassium carbonate / methanol / 1 h / 20 °C

5.1: triethylamine; trifluoromethane sulfonyl chloride / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

6.1: sodium hydroxide; water / ethanol / 12 h / 20 °C

7.1: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

8.1: sodium azide / N,N-dimethyl-formamide / 13 h / 20 °C / Inert atmosphere

With pyridine; dmap; sodium azide; N,O-bis-(trimethylsilyl)-acetamide; trifluoromethane sulfonyl chloride; sulfuric acid; water; acetic anhydride; potassium carbonate; acetic acid; triethylamine; sodium hydroxide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1300590-29-7
3,5-di-O-benzyl-4-(2-t-butyldiphenylsilyloxyethyl)-1,2-O-isopropylidene-α-D-erythropentofuranose

: 1300590-49-1
(2’R)-2’-azido-3’,5’-di-O-benzyl-4’-(2-tert-butyldiphenylsiloxyethyl)thymidine

Guidance literature:: Multi-step reaction with 7 steps

1.1: acetic anhydride; sulfuric acid; acetic acid / 2 h / 20 °C / Inert atmosphere

2.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 1.5 h / Inert atmosphere; Reflux

2.2: 3.5 h / 0 °C / Reflux; Inert atmosphere

3.1: potassium carbonate / methanol / 1 h / 20 °C

4.1: triethylamine; trifluoromethane sulfonyl chloride / dichloromethane / 1.5 h / 0 °C / Inert atmosphere

5.1: sodium hydroxide; water / ethanol / 12 h / 20 °C

6.1: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

7.1: sodium azide / N,N-dimethyl-formamide / 13 h / 20 °C / Inert atmosphere

With pyridine; sodium azide; N,O-bis-(trimethylsilyl)-acetamide; trifluoromethane sulfonyl chloride; sulfuric acid; water; acetic anhydride; potassium carbonate; acetic acid; triethylamine; sodium hydroxide; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;